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Neuro-arthritic diathesis



Neuro-arthritic diathesis is characterized by increased nervous excitability, a tendency to ketoacidosis, and a further predisposition to the development of obesity, interstitial nephritis, urolithiasis, atherosclerosis, diabetes mellitus, gout. Uric acid metabolism is a leading, but not the only laboratory marker.

Etiology. In the formation of the disease, on the one hand, the inheritance of pathological properties of metabolism is involved, on the other hand, nutrition in the family, mode, environment.

Pathogenesis. Of particular importance are the following disorders:

1) a high level of excitability at any level of reception;

2) impaired purine metabolism with an increase in their concentration in the blood and urine;

3) low acetylating ability of the liver and other, unencrypted mitochondrial defects.

Clinical manifestations. Already in infancy, increased nervous irritability is noted, which over time increases even more. Mental development is ahead of age norms: children are curious, lively, remember what they hear or read. Sometimes such children have nightly fears, tics, chore-like attacks, emotional lability. Periodically or suddenly after a short malaise, attacks of headache, nausea, vomiting, abdominal pain, smell of acetone from the mouth can occur, an acetone crisis develops.
During the crisis, the level of ketone bodies, ammonia, uric acid is increased in the blood test, and the pH decreases.

The diagnosis is established on the basis of anamnesis, clinical and laboratory data.

Differential diagnosis. It should be distinguished from neurosis, rheumatism, diabetes mellitus, etc.

Treatment. Rational regime and diet, hardening, walking, physical education. Exclusion of mental stress, restrict viewing of TV.

At the initial symptoms of an acetone crisis or its precursors give sweet tea, fruit juices, alkaline mineral waters. It is advisable to hospitalize the child in a hospital. They make a cleansing enema, gastric lavage is done to better remove ketone bodies from the intestines.

Essential or vitamin B 12 is used. In case of acetonemic vomiting, the treatment is aimed at combating acitosis (elimination and elimination of ketone bodies): 5% Cn glucose solution, 0.9% C sodium chloride solution are introduced. At a blood pH below 7.2, a 4% sodium bicarbonate solution is administered.

Prevention Compliance with the regime of the day of the child, a balanced diet, protecting the child from mental stress.

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Neuro-arthritic diathesis

  1. Neuro-arthritic diathesis
    Neuro-arthritic diathesis is a combination of hereditarily determined congenital and acquired morphological and functional features of the body, characterized by impaired purine metabolism or a parallel impaired functioning of organs and systems (adrenal glands, liver, central nervous system, etc.). Neuro-arthritic diathesis is characterized by increased nervous excitability,
  2. Neuro-arthritic diathesis
    Neuro-arthritic diathesis (NAD) refers to constitutional abnormalities with impaired uric acid metabolism, accumulation of purines in the body, and instability of lipid and carbohydrate metabolism. Neuro-arthritic diathesis is a hereditarily determined dysmetabolic syndrome, which is based on impaired purine metabolism and mediator functions of the nervous system. Characterized by increased
  3. Neuro-arthritic diathesis
    -s-m functional changes in the nervous system: a sharp increase in excitability, chore-like attacks, nightly fears, fever, migraines, anorexia, vomiting, biliary dyskinesia, intestinal dyskinesia, urinary incontinence, dysuria -th arthritism: myalgia, polyarthralgia lesions of the skin and mucous membranes: allergic manifestations - metabolic disorders: intoxication during the crisis, acetonemic vomiting,
  4. Types of Diathesis
    The Constitution is a combination of relatively stable morphological and functional properties of a person, due to heredity, age, and prolonged intense environmental influences, which determines the functionality and reactivity of the body. Diathesis is a genetically determined characteristic of an organism that determines the uniqueness of its adaptive reactions and
  5. Anomalies of the constitution (diathesis)
    The concept of “constitutional anomalies” (diathesis) was introduced into clinical pediatrics in the late XIX - early XX centuries and corresponded to the concept of “hereditary predisposition”, which was due to insufficient information on heredity, genetic and molecular mechanisms of the development of diseases. The development of genetics and molecular biology has made it possible to decipher many aspects of heredity and
  6. Exudative-catarrhal diathesis
    Exudative-catarrhal diathesis is the ability of hereditarily determined congenital and acquired body properties to respond with an increased reaction of the skin and mucous membranes to individual external stimuli. Exudative-catarrhal diathesis is caused by genetic factors (genetic burden - in 70-80% of children), age-related features of the enzyme system of the digestive tract and
  7. Lymphatic-hypoplastic diathesis
    Lymphatic-hypoplastic diathesis is a combination of hereditarily determined congenital and acquired morphofunctional characteristics of the child’s body, which determine the possibility of developing thymus and lymphatic apparatus hypertrophy in children, adrenal gland hypoplasia, thyroid and parathyroid glands, elements of the cardiovascular system and some other
  8. Exudative-catarrhal diathesis
    Exudative-catarrhal diathesis is a peculiar state of reactivity in young children, characterized by a tendency to recurrent infiltrative-desquamous lesions of the skin and mucous membranes, the development of pseudo-allergic reactions and a prolonged course of inflammatory processes, lymphoid hyperplasia, and lability of water-salt metabolism. Etiology and pathogenesis are not completely
  9. Exudative-catarrhal diathesis
    Exudative-catarrhal diathesis (ECD) is a constitutional feature of the child, in which there is a tendency to recurrent infiltrative-desquamous lesions of the skin and mucous membranes, the development of allergic reactions, the prolonged course of inflammatory processes, lymphoid hyperplasia, and the lability of water-salt metabolism. E p i d e m and o logue. According to domestic authors,
  10. Lymphatic diathesis
    Lymphatic diathesis (lympho-hypoplastic) is a hereditary deficiency of the lymphatic system associated with a decrease in the function of the thymus gland as the main organ that controls the maturation of lymphocytes. The disease is manifested by a generalized persistent increase in lymph nodes, endocrine system dysfunction (decreased adrenal function,
  11. Hemorrhagic diathesis
    HEMORRHAGIC DIATHESIS (HD) - a group of congenital or acquired diseases and syndromes, the main clinical manifestation of which is increased bleeding - a tendency to repeated bleeding or hemorrhage that occurs spontaneously or after minor injuries. Increased bleeding can be: 1) the main manifestation of the disease (for example, thrombocytopenic
  12. Lymphatic-hypoplastic diathesis
    Lymphatic-hypoplastic diathesis (LHD) - congenital dysregulatory endocrinopathy, manifested by a violation of adaptation to the external environment and transient immunological deficiency; a condition characterized by hyperplasia of lymphoid tissue, transient immunodeficiency, insufficient development of chromaffin tissue. E p i d e m and o logue. It is detected more often in children from 2 to 6 years old with a frequency of about
  13. Exudative-catarrhal diathesis
    -sm skin lesions: gneiss, seborrhea, milk crust, diaper rash, eczema dry and weeping, neurodermatitis, pruritus -sm lesions of the mucous membranes: "geographical language", conjunctivitis, blepharitis, rhinitis, pharyngitis, laryngitis, bronchitis, vulvovaginitis , bowel dysfunction - cm functional changes in the nervous system - hyperplastic cm: enlargement of peripheral lymph nodes - criteria
  14. Lymphatic-hypoplastic diathesis
    - hyperplastic cm: generalized hyperplasia of the lymphoid tissue - cm functional changes in the nervous system: depression, lethargy, adynamia, decreased tendon reflexes -R: increased mediastinal lymph nodes, thymomegaly; , drip heart, functional lability of the cardiovascular system
  15. Bleeding with hemorrhagic diathesis
    Hemophilia Hemophilia is a hereditary disease in which there is a deficiency of VIII, IX or XI coagulation factors. Symptoms: • heavy and prolonged bleeding during injuries; • hemorrhages in large joints; • subcutaneous, intramuscular 'hematomas; • pain in joints and muscles; • hematuria; • gastrointestinal bleeding; • anemic syndrome (weakness,
  16. Exudative-catarrhal diathesis - ECD
    Diathesis in essence is not yet a disease, it is a predisposition, a special tendency of the skin and mucous membranes to inflammatory processes. This condition leads to violations of the NS and internal organs. ECD is detected most often at the age of 3-6 months, and its pronounced symptoms can be observed during the first 2 years of life. Etiology. In the occurrence of this anomaly the constitution has
  17. HEMORRHAGIC DIATHESIS
    - a group of acquired or hereditary diseases, the main clinical sign of which is increased bleeding. The main clinical manifestations In thrombocytopenic purpura, the main symptoms of the disease are skin hemorrhages and bleeding from the mucous membranes. Symptoms of tourniquet and pinch are usually positive. Skin hemorrhages occur spontaneously or after
  18. HEMORRHAGIC DIATHESIS
    4 mechanisms of hemostasis: 1. Vascular-platelet hemostasis. Linked to platelets. Their function is primarily angiotrophic, they play a leading role in maintaining the normal resistance and function of microvessels. They are the natural breadwinners of the vascular wall; if endothelial cells do not receive platelet top dressing, then dystrophy occurs, the vascular wall begins
  19. PLANTS CAUSING HEMORRHAGIC DIATHESIS (MULTIPLE BLEEDING)
    Melilotus - Melilotus (Fig. 31). One or two year old bean plant. When rubbing between the fingers emits a sharp specific smell. The stem is straight, branched. The flowers are white or yellow. The most common species are yellow clover, or medicinal, with yellow flowers and white clover with white flowers, which is often cultivated as a fodder plant. Both of these types of sweet clover are pretty
  20. Causes of nervous diseases and the main forms of disorders of the nervous system
    The external environment interacts closely with the human body. Various adverse changes in external conditions, in particular climatic, the influence of various biological factors, for example pathological agents, can adversely affect the human body and its nervous system. The nature of food, housing conditions, etc. are also important. In some cases, as reasons
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