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Systemic lupus erythematosus

Systemic lupus erythematosus is a chronic polysyndromic disease of connective tissue and vessels, develops in connection with the genetically caused imperfection of immunoregulatory processes.

Etiology. It is assumed the importance of a viral infection against the background of genetically determined immunity disorders.

Pathogenesis: circulating antibodies are formed, of which antinuclear antibodies are an important diagnostic and pathogenetic value; the formation of circulating immune complexes that are deposited on the basal membranes of various organs, causing their damage and inflammation. Hyperreactivity of humoral immunity is associated with impaired cellular immunoregulation. Recently, the importance of hyperestrogenemia is attached, accompanied by a decrease in clearance. Family-genetic predisposition, sick more often girls, women. Provoking factors: insolation, pregnancy, abortion, childbirth, the onset of menstrual function, infection (especially in adolescents), drug or postvaccinal reaction.

Clinic. The disease begins gradually, with recurrent polyarthritis, asthenia. Less common is acute (high fever, dermatitis, acute polyarthritis). In the future there is a recurrent course. Polyarthritis, polyarthralgia is an early symptom of the disease. Defeat of small joints of hands, wrist, ankle, less often - knee joints. Erythematous rashes on the face skin in the form of a "butterfly", in the upper half of the chest in the form of a decollete, on the limbs is also a characteristic sign of systemic lupus erythematosus. Polyserositis, dermatitis, polyarthritis - diagnostic triad. Characteristic is the defeat of the cardiovascular system with the development of pericarditis, to which myocarditis joins. The warty endocarditis of Liebman-Sachs with mitral, aortic and tricuspid valves is comparatively often observed. Vascular damage with the development of Raynaud's syndrome (long before the typical picture of the disease), lesions of small and large vessels with the corresponding clinical symptoms. Lung infection can be associated with a major disease in the form of lupus pneumonitis, manifested by coughing, shortness of breath, with auscultation in the lower sections of the lungs wet rales. When X-ray examination can be found enhanced pulmonary pattern and deformation of the lung pattern in the basal parts of the lungs, focal shadows are revealed. In the study of the gastrointestinal tract, aphthous stomatitis is detected, dyspeptic syndrome and anorexia develop.
Pain abdominal syndrome develops with the involvement of the peritoneal process of the peritoneum, development of vasculitis mesenteric, splenic, segmental ileitis develops. The defeat of the reticuloendothelial system manifests itself in the form of an increase in all groups of lymph nodes, enlargement of the liver, spleen. Lupus hepatitis develops very rarely, but the enlarged liver can be detected with heart failure, pankarditis, pronounced exudate pericarditis, with the development of fatty liver. Lupus diffuse glomerulonephritis (lupus-nephritis) develops in some patients during the generalization of the process. You can meet different variants of kidney damage: urinary syndrome, nephritic syndrome, nephrotic syndrome. When recognizing lupus jade, puncture biopsy with immunomorphological and electron microscopic studies of the kidney biopsy is of great importance. Development of renal pathology with relapsing articular syndromes, fever, increased ESR, which requires the exclusion of nephritis of lupus genesis. It must be remembered that every fifth patient with nephrotic syndrome can have systemic lupus erythematosus and neuropsychic involvement in patients can develop in all phases of the disease. In the initial stage, the asthenovegetative syndrome is diagnosed, then there are characteristic signs of the defeat of the central and peripheral nervous system in the form of encephalitis, polyneuritis, myelitis. Very rarely can epileptiform seizures develop. It is possible to develop hallucinations (auditory or visual), delusions, etc. Diagnosis based on clinical and laboratory data that have a particular diagnostic value determines a large number of LE cells, high titers of antibodies to DNA, especially native DNA, to deoxyribonucleoprotein, Sm -antigen.

Treatment. Nonsteroidal anti-inflammatory agents and aminoquinoline derivatives are indicated. Nonsteroidal anti-inflammatory drugs are prescribed for articular syndrome. Immunosuppressants, B vitamins, ascorbic acid during the spring-autumn course. Patients are prescribed treatment in sanatoriums of local type (cardiological, rheumatological). Climatological, physiotherapeutic treatment is contraindicated, since ultraviolet irradiation, insolation and hydrotherapy can cause exacerbation of the disease.

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Systemic lupus erythematosus

    Systemic lupus erythematosus (SLE) is a systemic autoimmune disease of an unknown etiology, which is based on a genetically determined impairment of immunoregulatory mechanisms that determines the formation of a wide range of organonesspecific autoantibodies to various components of the nucleus and the formation of immune complexes that cause the development of immune inflammation in the tissues of various organs.
  2. Systemic lupus erythematosus
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  3. Systemic lupus erythematosus
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  4. Systemic lupus erythematosus.
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    - chronic systemic autoimmune disease of connective tissue and vessels, characterized by severe course, steady progression and polymorphism of clinical manifestations. The main clinical manifestations The most frequent clinical sign of systemic lupus erythematosus is the involvement of joints in the form of pronounced migrating polyarthralgia or arthritis. Deformation of the joints
    Systemic lupus erythematosus (SLE): nonspecific autoimmune disease of the body, which is accompanied by lesions caused by cytotoxic antibodies and the deposition of immune complexes. SLE is observed in many species of mammals (man, mouse, monkey, cat, dog and horse). As a rule, the disease occurs in subacute or - more often - in a chronic form, accompanied by
  7. Systemic lupus erythematosus
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  8. Systemic lupus erythematosus (code? 32)
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  15. lupus erythematosus
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