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Systemic lupus erythematosus



Systemic lupus erythematosus is a chronic polysyndromic disease of the connective tissue and blood vessels, developing in connection with the genetically determined imperfection of immunoregulatory processes.

Etiology. The significance of viral infection against the background of genetically determined immunity disorders is assumed.

Pathogenesis: circulating antibodies are formed, of which antinuclear antibodies are of important diagnostic and pathogenetic importance; the formation of circulating immune complexes that are deposited on the basement membranes of various organs, causing their damage and inflammation. Hyperreactivity of humoral immunity is associated with impaired cellular immunoregulation. Recently, the importance of hyperestrogenia is attached, accompanied by a decrease in clearance. Family genetic predisposition, girls, women are more likely to get sick. Provocative factors: insolation, pregnancy, abortion, childbirth, the onset of menstrual function, infection (especially in adolescents), drug or post-vaccination reaction.

Clinic. The disease begins gradually, with recurrent polyarthritis, asthenia. Less common is an acute onset (high fever, dermatitis, acute polyarthritis). In the future, there is a recurrent course. Polyarthritis, polyarthralgia - an early symptom of the disease. The defeat of the small joints of the hands, wrist, ankle, less often - the knee joints. Erythematous rash on the skin of the face in the form of a butterfly, in the upper half of the chest in the form of a neckline, on the extremities is also a characteristic sign of systemic lupus erythematosus. Polyserosis, dermatitis, polyarthritis - diagnostic triad. Characterized by damage to the cardiovascular system with the development of pericarditis, which is joined by myocarditis. The warty endocarditis of Liebman-Sachs with lesions of the mitral, aortic and tricuspid valves is relatively often observed. Damage to blood vessels with the development of Raynaud's syndrome (long before the typical picture of the disease), the defeat of small and large vessels with appropriate clinical symptoms. The defeat of the lungs may be associated with the underlying disease in the form of lupus pneumonitis, manifested by coughing, shortness of breath, with auscultation in the lower regions of the lungs moist rales. X-ray examination reveals an enhanced pulmonary pattern and deformity of the pulmonary pattern in the basal regions of the lungs, and focal shadows are detected. In the study of the gastrointestinal tract revealed aphthous stomatitis, dyspeptic syndrome and anorexia develops.
Abdominal pain syndrome develops with the involvement of the peritoneum in the pathological process, mesenteric and splenic vasculitis develops, segmental ileitis develops. The defeat of the reticuloendothelial system is manifested in the form of an increase in all groups of lymph nodes, an increase in the liver, spleen. Lupus hepatitis develops very rarely, but an enlarged liver can be detected in heart failure, pancarditis, severe pericardial effusion, and in the development of fatty degeneration of the liver. Lupus diffuse glomerulonephritis (lupus nephritis) develops in some patients during the process of generalization. You can find different types of kidney damage: urinary syndrome, nephritic syndrome, nephrotic syndrome. When recognizing lupus nephritis, puncture biopsy with immunomorphological and electron microscopic studies of the kidney biopsy is of great importance. The development of renal pathology with recurrent articular syndromes, fever, increased ESR, which requires to exclude lupus nephritis. It must be remembered - every fifth patient with nephrotic syndrome can have systemic lupus erythematosus and the neuropsychic sphere in patients can develop in all phases of the disease. At the initial stage, the asthenovegetative syndrome is diagnosed, then characteristic signs of damage to the central and peripheral nervous system appear in the form of encephalitis, polyneuritis, myelitis. Very rarely, epileptiform seizures may develop. Perhaps the development of hallucinations (auditory or visual), delusional states, etc. Diagnostics based on clinical and laboratory data that have particular diagnostic value, determines a large number of LE cells, high antibody titers to DNA, especially to native DNA, to deoxyribonucleoprotein, Sm antigen.

Treatment. Non-steroidal anti-inflammatory drugs and aminoquinoline derivatives are shown. Nonsteroidal anti-inflammatory drugs prescribed for articular syndrome. Immunosuppressants, B vitamins, ascorbic acid during the spring and autumn course. Patients are prescribed treatment in local type resorts (cardiological, rheumatological). Climatobalneological, physiotherapy treatment is contraindicated, since ultraviolet radiation, insolation and hydrotherapy can cause exacerbation of the disease.

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Systemic lupus erythematosus

  1. SYSTEM RED LADY
    Systemic lupus erythematosus (SLE) is a systemic autoimmune disease of unknown etiology based on a genetically determined disorder of immunoregulatory mechanisms that determines the formation of a wide spectrum of organ-specific autoantibodies to various components of the nucleus and the formation of immune complexes that cause the development of immune inflammation in the tissues of various organs.
  2. Systemic lupus erythematosus
    There are acute and chronic forms of lupus erythematosus. The acute form is characterized by pale red and red edematous rashes, often on the face, which merge into spots. Rashes can be found on the body, buttocks, limbs, often on the hands and fingers, less often on the mucous membranes. They resemble seborrheic eczema or exudative erythema. Sometimes foci are combined with bubbles and
  3. Systemic lupus erythematosus
    Systemic lupus erythematosus (SLE) is an acute or chronically occurring systemic disease with severe autoimmunization characterized by a predominant lesion of the skin, blood vessels, and kidneys. • Mostly young women get sick. • Insolation and taking certain medications are often provoking factors. • The processes of autoimmunization are accompanied by the appearance of antinuclear autoantibodies to
  4. Systemic lupus erythematosus.
    Systemic lupus erythematosus is a disease of the autoimmune nature. With the development of the disease by the patient's body, antibodies are produced to the nuclear substances of their own cells. Mostly sick girls - teenagers. Fever can be constant for weeks and months. Its reason is long incomprehensible. Rash. "Lupus butterfly" - a group of small and medium in size
  5. SYSTEM RED LADY
    - chronic systemic autoimmune disease of the connective tissue and blood vessels, characterized by severe course, steady progression and polymorphism of clinical manifestations. Main clinical manifestations The most common clinical sign of systemic lupus erythematosus is joint damage in the form of marked migrating polyarthralgia or arthritis. Joint deformity
  6. SYSTEM RED LADY
    Systemic lupus erythematosus (SLE): a nonspecific autoimmune disease of the body, which is accompanied by lesions caused by cytotoxic antibodies and the deposition of immune complexes. SLE is observed in many species of mammals (human, mouse, monkey, cat, dog and horse). As a rule, the disease occurs in a subacute or - more often - in a chronic form, accompanied by
  7. Systemic lupus erythematosus
    Systemic lupus erythematosus (SLE) is a chronic polysyndromic disease, predominantly in females, developing against the background of genetically determined imperfections of immunoregulatory processes, leading to uncontrolled production of antibodies to its own cells and their components with the development of autoimmune and immunocomplex inflammation. EPIDEMIOLOGY. Accurate data about
  8. Systemic lupus erythematosus (code? 32)
    Definition Systemic lupus erythematosus is a disease that develops on the basis of a genetically determined imperfection of immunoregulatory processes, leading to the formation of antibodies to its own cells and their components, the emergence of immunocomplex inflammation that affects many organs and systems (MM Ivanova). Statistics. Sickness is very variable, varies in different regions
  9. 3.3. SYSTEM RED LADY
    NSAIDs are prescribed to relieve constitutional and musculoskeletal manifestations of SLE, as well as moderately severe serositis. Recommended: diclofenac (tab. 25 mg) at 75-150 mg / day, ketoprofen (cap. 50 mg, tab. Forte 100 mg) at 100-300 mg / day, lornoxicam (tab. 4 and 8 mg) according to 8-16 mg / day., Meloxicam (tab. 7.5 and 15 mg) at 7.5-15 mg / day., Celecoxib (cape. 100 and 200 mg) 200-400 mg / day.,
  10. Systemic lupus erythematosus
    -cutaneous cm: butterfly, erythema of the periungual, periarticular, other localization, capillaries, polymorphic rashes, cheilitis, enanthema, dystrophy of the skin, hair - articular sm: polyarthritis, polyarthralgia - muscular sm: myositis, myalgia –s- m Rayno-pulmonary sm: pneumonitis, pleurisy, pneumosclerosis - renal sm: nephritis - cardiac sm: myocarditis, endocarditis, pericarditis, myocardial dystrophy,
  11. 80.DIFFUSE DISEASES OF THE CONNECTIVE TISSUE. CLASSIFICATION. ETIOLOGY, PATHOGENESIS. SYSTEM RED LADY. CLINIC, DIAGNOSTICS, TREATMENT PRINCIPLES.
    Diffuse diseases of comp. Tk (DBST) - a group of nosological forms, systemic autoimmune and immuno-complex inflammation or excessive fibrosis education (with systemic scleroderma) , mixed connective tissue disease and rheumatic polymyalgia. Etiology - can
  12. Pathology of the immune system. Hypersensitivity Reactions. Autoimmunization and autoimmune diseases. Amyloidosis. Systemic lupus erythematosus. Scleroderma. Immune Deficiency Syndrome (AIDS).
    1. Forms of immunity 1. focal 3. specific 2. diffuse 4. nonspecific 2. Mechanical protection is provided by 1. skin 4. peripheral nerves 2. blood 5. vascular mucosa 3. vascular endothelium 3. Humoral nonspecific components of the immune response 1. sweat 4. mesangiocytes 2. macrophages 5. lacrimal fluid 3. neutrophils 4. To establish compliance: ORGANIZING RESPONSIBLE
  13. Neonatal lupus erythematosus
    DEFINITION Newborns from mothers with systemic lupus erythematosus and other diffuse connective tissue diseases may have transient dermal lupus, heart rhythm disturbances (congenital heart block) and hematological disorders (thrombocytopenia, leukopenia, hemolytic anemia), as well as immunological signs of systemic lupus erythematosus what is called
  14. lupus erythematosus
    Lupus erythematosus - collagenosis, an important role in the pathogenesis of which is a violation of the regulatory function of T-lymphocytes, the appearance of immune complexes and their deposition in the tissues. Mostly women are ill (about 90%) at the age of 20-45 years. The causes of the disease are unknown. It is assumed that provoking factors (some chemicals, drugs, infection) in combination with
  15. lupus erythematosus
    Lupus erythematosus is a group of connective tissue diseases that have autoimmune pathogenesis and affect predominantly exposed skin and internal organs. Etiology and pathogenesis. Hereditary predisposition and, apparently, viral infection, which contribute to the development of autoimmune processes, have a leading role in the etiology of lupus erythematosus. Clinic. Allot
  16. RED LADY (LUPUS ERYTHEMATODES)
    Etiopathogenesis. Dermatosis is etiologic. Theories of the origin of lupus erythematosus: 1. Autoimmune theory - it plays the main role. In the serum of patients with lupus erythematosus detect a high level? - globulins, among which an unusual protein - macroglobulin, the so-called anti-nuclear factor, damaging the nucleus of cells, especially leukocytes. In peripheral blood and
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