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Systemic lupus erythematosus

Systemic lupus erythematosus is a chronic polysyndromic disease of connective tissue and blood vessels, develops in connection with a genetically caused imperfection of immunoregulatory processes.

Etiology. The significance of a viral infection against the background of genetically determined immune disorders is assumed.

Pathogenesis: circulating antibodies are formed, of which antinuclear antibodies are of important diagnostic and pathogenetic value; the formation of circulating immune complexes that are deposited on the basement membranes of different organs, causing damage and inflammation. The hyperreactivity of humoral immunity is associated with a violation of cellular immunoregulation. Recently, hyperestrogenemia has been given importance, accompanied by a decrease in clearance. Family genetic predisposition, girls, women are more often sick. Provoking factors: insolation, pregnancy, abortion, childbirth, the onset of menstrual function, infection (especially in adolescents), drug or post-vaccination reaction.

Clinic. The disease begins gradually, with recurrent polyarthritis, asthenia. Less common is acute onset (high fever, dermatitis, acute polyarthritis). In the future, a relapsing course is noted. Polyarthritis, polyarthralgia - an early symptom of the disease. The defeat of small joints of the hands, wrist, ankle, less often - knee joints. Erythematous rashes on the face skin in the form of a “butterfly”, in the upper half of the chest in the form of a décolleté, on the extremities is also a characteristic sign of systemic lupus erythematosus. Polyserositis, dermatitis, polyarthritis - a diagnostic triad. The defeat of the cardiovascular system with the development of pericarditis, to which myocarditis joins, is characteristic. Relatively often observed warty endocarditis of Liebman-Sachs with lesions of the mitral, aortic and tricuspid valves. Vascular damage with the development of Raynaud's syndrome (long before the typical picture of the disease), damage to small and large vessels with corresponding clinical symptoms. Damage to the lungs can be associated with the underlying disease in the form of lupus pneumonitis, manifested by coughing, shortness of breath, with auscultation in the lower parts of the lungs wet rales. An X-ray examination reveals an enhanced pulmonary pattern and deformation of the pulmonary pattern in the basal parts of the lungs; focal-like shadows are revealed. When examining the gastrointestinal tract, aphthous stomatitis is detected, dyspeptic syndrome and anorexia develop.
Abdominal pain syndrome develops when the peritoneum is involved in the pathological process, mesenteric, splenic vasculitis develops, segmental ileitis develops. The defeat of the reticuloendothelial system is manifested in the form of an increase in all groups of lymph nodes, an increase in the liver, spleen. Lupus hepatitis develops very rarely, but an enlarged liver can be detected with heart failure, pancreatitis, severe effusion pericarditis, with the development of fatty liver. Lupus diffuse glomerulonephritis (lupus nephritis) develops in some patients during the generalization of the process. You can meet different options for kidney damage: urinary syndrome, nephritic syndrome, nephrotic syndrome. When recognizing lupus nephritis, puncture biopsy with immunomorphological and electron microscopic studies of kidney biopsy is of great importance. The development of renal pathology with recurrent articular syndromes, fever, elevated ESR, which requires the elimination of lupus nephritis. It must be remembered that every fifth patient with nephrotic syndrome can have systemic lupus erythematosus and a lesion of the neuropsychic sphere in patients can develop in all phases of the disease. In the initial stage, asthenovegetative syndrome is diagnosed, then characteristic signs of damage to the central and peripheral nervous system appear in the form of encephalitis, polyneuritis, myelitis. Very rarely, epileptiform seizures can develop. It is possible to develop hallucinations (auditory or visual), delusional states, etc. Diagnosis based on clinical and laboratory data that have special diagnostic value determines a large number of LE cells, high titers of antibodies to DNA, especially to native DNA, to deoxyribonucleoprotein, Sm antigen.

Treatment. Non-steroidal anti-inflammatory drugs and aminoquinoline derivatives are indicated. Nonsteroidal anti-inflammatory drugs are prescribed for articular syndrome. Immunosuppressants, B vitamins, ascorbic acid during the spring-autumn course. Patients are prescribed treatment in local sanatoriums (cardiological, rheumatological). Climatic-balneological, physiotherapeutic treatment is contraindicated, since ultraviolet radiation, insolation and hydrotherapy can cause an exacerbation of the disease.

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Systemic lupus erythematosus

  1. Systemic lupus erythematosus
    Systemic lupus erythematosus (SLE) is a systemic autoimmune disease of unknown etiology, which is based on a genetically determined violation of immunoregulatory mechanisms, which determines the formation of a wide range of organ-specific autoantibodies to various components of the nucleus and the formation of immune complexes that cause the development of immune inflammation in the tissues of various organs.
  2. Systemic lupus erythematosus
    There are acute and chronic forms of lupus erythematosus. The acute form is characterized by pale red and red swollen rashes, often on the face, which merge into spots. Rashes can be found on the trunk, buttocks, limbs, more often on the hands and fingers, less often on the mucous membranes. They resemble seborrheic eczema or exudative erythema. Sometimes the foci are combined with bubbles and
  3. Systemic lupus erythematosus
    Systemic lupus erythematosus (SLE) is an acute or chronically occurring systemic disease with severe autoimmunization, characterized by a predominant lesion of the skin, blood vessels and kidneys. • Mostly young women are ill. • Provoking factors are often insolation and taking certain medications. • Autoimmunization processes are accompanied by the appearance of antinuclear autoantibodies to
  4. Systemic lupus erythematosus.
    Systemic lupus erythematosus is a disease of an autoimmune nature. With the development of the disease, the patient’s body produces antibodies to the nuclear substances of its own cells. Mostly sick teenage girls. The fever can be constant for many weeks and months. The reason for it is long incomprehensible. Rash. "Lupus butterfly" - a group of small and medium-sized
  5. Systemic lupus erythematosus
    - a chronic systemic autoimmune disease of the connective tissue and blood vessels, characterized by severe course, steady progression and polymorphism of clinical manifestations. The main clinical manifestations The most common clinical sign of systemic lupus erythematosus is joint damage in the form of severe migratory polyarthralgia or arthritis. Joint deformation
  6. Systemic lupus erythematosus
    Systemic lupus erythematosus (SLE): A nonspecific autoimmune disease of the body that is accompanied by lesions caused by cytotoxic antibodies and the deposition of immune complexes. SLE is observed in many species of mammals (human, mouse, monkey, cat, dog and horse). As a rule, the disease proceeds in a subacute or - more often - in a chronic form, accompanied by
  7. Systemic lupus erythematosus
    Systemic lupus erythematosus (SLE) is a chronic polysyndromic disease, mainly in females, which develops against the background of genetically caused imperfection of immunoregulatory processes, which leads to uncontrolled production of antibodies to own cells and their components with the development of autoimmune and immunocomplex inflammation. EPIDEMIOLOGY. Accurate data on
  8. Systemic lupus erythematosus (code? 32)
    Definition Systemic lupus erythematosus is a disease that develops on the basis of genetically caused imperfection of immunoregulatory processes, leading to the formation of antibodies to own cells and their components, the occurrence of immunocomplex inflammation that affects many organs and systems (M.M. Ivanova). Statistics. Soreness is very variable, varies in different regions
  9. 3.3. Systemic lupus erythematosus
    NSAIDs are prescribed for the relief of constitutional and musculoskeletal manifestations of SLE, as well as moderately severe serositis. Recommended: diclofenac (tab. 25 mg) at 75-150 mg / day., Ketoprofen (cap. 50 mg, tab. Forte 100 mg) at 100-300 mg / day., Lornoxicam (tables. 4 and 8 mg). 8-16 mg / day., Meloxicam (tab. 7.5 and 15 mg) at 7.5-15 mg / day., Celecoxib (cap. 100 and 200 mg) 200-400 mg / day.,
  10. Systemic lupus erythematosus
    -skin cm: butterfly, erythema periungual, periarticular, other localization, capillaries, polymorphic rashes, cheilitis, enanthema, dystrophy of the skin, hair-articular cm: polyarthritis, polyarthralgia -muscular cm: myositis, myalgia Rayna-pulmonary cm: pneumonitis, pleurisy, pneumosclerosis-renal cm: nephritis -cardial cm: myocarditis, endocarditis, pericarditis, myocardial dystrophy,
    Diffuse diseases of the connective tissue (DBST) - a group of nosological forms, x-systemic autoimmune and immuno-complex inflammation or excessive fibrozo formation (with systemic scleroderma) DBST includes: SLE, systemic scleroderma, dermatomyositis, Sjogren's syndrome, diffuse ectosis mixed connective tissue disease and rheumatic polymyalgia Etiology - possible
  12. Pathology of the immune system. Hypersensitivity reactions. Autoimmunization and autoimmune diseases. Amyloidosis. Systemic lupus erythematosus. Scleroderma. Immune Deficiency Syndrome (AIDS).
    1. Forms of immunity 1. focal 3. specific 2. diffuse 4. non-specific 2. Mechanical protection is provided by 1. skin 4. peripheral nerves 2. blood 5. vascular mucosa 3. vascular endothelium 3. Humoral non-specific components of the immune response 1. sweat 4. mesangiocytes 2. macrophages 5. lacrimal fluid 3. neutrophils 4. To establish compliance: ORGAN APPROPRIATE
  13. Neonatal lupus erythematosus
    DEFINITION Newborns from mothers with systemic lupus erythematosus and other diffuse connective tissue diseases can have transient skin lupus erythematosus lesions, cardiac arrhythmias (congenital heart block) and hematologic disorders (thrombocytopenia, leukopenia, hemolytic anemia), as well as immunological signs of systemic lupus erythematosus which is called
  14. lupus erythematosus
    Lupus erythematosus is collagenosis, an important role in the pathogenesis of which is played by a violation of the regulatory function of T-lymphocytes, the appearance of immune complexes and their deposition in tissues. Mostly women (about 90%) aged 20–45 years are ill. The causes of the disease are unknown. Provoking factors (certain chemicals, drugs, infection) are thought to be combined with
  15. lupus erythematosus
    Lupus erythematosus is a group of connective tissue diseases that have autoimmune pathogenesis and affect mainly exposed areas of the skin and internal organs. Etiology and pathogenesis. The leading importance in the etiology of lupus erythematosus is a hereditary predisposition and, apparently, a viral infection, which contribute to the development of autoimmune processes. Clinic. Allocate
    Etiopathogenesis. Dermatosis is polyetiologic. Theories of the origin of lupus erythematosus: 1. Autoimmune theory - it plays the main role. In the blood serum of patients with lupus erythematosus detect a high level? - globulins, among which an unusual protein was revealed - macroglobulin, the so-called antinuclear factor that damages the nuclei of cells, especially leukocytes. In peripheral blood and
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