about the project
Medical news
For authors
Licensed books on medicine
<< Previous Next >>

Treatment of tissue helminthiases

Treatment of patients with tissue helminthiases, regardless of severity, is carried out in a hospital. In the acute period of the disease, with severe forms of trichinosis, toxocariasis, cysticercosis, complicated forms of echinococcosis (rupture or suppuration of an echinococcal cyst), bed rest is prescribed. A complete diet enriched with vitamins is shown.

Etiotropic therapy. It is indicated for all forms of tissue helminthiases, however, the spectrum of effective antiparasitic agents is extremely narrow, of which albendazole, mebendazole and praziquantel are used in the Russian Federation.

Universal and one of the most effective means is NEMOZOL (albendazole preparation).

The drug has a wide spectrum of anthelmintic activity, which is especially important for mixed invasions, since it has a therapeutic effect in lesions with round, flat (including pork tapeworm) worms and their larvae. Nemozole has an inhibitory effect on beta-tubulin polymerization in parasite cells. This leads to destruction of the cytoplasmic microtubules of the cells of the intestinal tract of helminths, a change in biochemical processes (suppression of glucose utilization), blockade of the movement of secretory granules and other organelles in the muscle cells of worms, which leads to their death. Unlike mebendazole preparations (vermox, vormin), which are practically not absorbed in the gastrointestinal tract, therefore do not have a sufficient effect in toxocariasis and trichinosis and are practically not effective in echinococcosis and cysticercosis, nemozole is absorbed in the gastrointestinal tract by 30%, and intake of fatty foods increases absorption the drug is 5 times what should be considered when appointing it.

Nemozole exists in the form of 400 mg tablets in one tablet for adults and adolescents and in the form of a suspension of 100 mg / 5 ml for children over 2 years of age. Pregnant women are not recommended.

Dosage and administration.
The drug is used orally during meals. Course and single doses are selected depending on the type of helminthiasis and body weight of the patient.

With toxocariasis and trichinosis, nemozole (albendazole) is prescribed for adults and patients over 14 years old with a body weight of more than 60 kg 400 mg 2 times a day, for patients with a body weight of less than 60 kg - 200 mg 2 times a day. For children, the drug is prescribed at a rate of 10 mg / kg / day in two divided doses. The course of treatment is from 7 to 14 days, depending on the duration and severity of the disease.

With echinococcosis and cysticercosis, nemozole (albendazole) is prescribed for adults and patients over 14 years of age with a body weight of more than 60 kg 400 mg 2 times a day, adults with a body weight of less than 60 kg and for children in a dose of 15 mg / kg / day . The course of therapy is 28 days. For the treatment of echinococcosis, it is recommended to carry out 3 courses of therapy with an interval of 2 weeks. In cases of uncomplicated liver echinococcosis, medication is possible. With a subarachnoid location of the cysticercus or its localization in the furrows of the brain, nemosol (albendazole) is used for at least 30 days, if necessary, the course of therapy can be repeated, after 2 to 3 weeks.

Of the other antiparasitic drugs, it is possible to use: with toks o akoz e - mebendazole (vermox, vormin) inside at the rate of adults at 100 mg twice a day, for children - 5 mg / kg / day in two divided doses 7-10 days; if necessary, repeated courses are possible;

with t and x inellez - mebendazole (vermox, vormin) inside, at the rate of adults, 100 mg three times a day, children - 5 mg / kg / day in two doses with a course of 5-7-12 days;

with cysticercosis - praziquantel 50-100 mg / kg / day in 3 divided doses, 30 days course (with neurocysticercosis in combination with prednisolone (usually in combination with prednisolone).

<< Previous Next >>
= Skip to textbook content =

Treatment of tissue helminthiases

  1. Antonov M.M .. Tissue helminthiases in adults and children (epidemiology, clinic, diagnosis, treatment, prevention), 2004

  2. Immunopathogenesis of tissue helminthiases
    Helminth larvae formed after infection of a person from the intestines penetrate into the blood and are hematogenously carried to organs, where they can remain viable for many years, determining the clinical picture of the disease. In some cases, re-migration of larvae is possible. Tissue migration is associated with serious pathological changes in the human body, as specific,
  3. Laboratory diagnosis of tissue helminthiases
    Laboratory methods for tissue helminthiases, as a rule, are crucial for making and registering a diagnosis and selecting rational etiotropic therapy. In connection with the peculiarities of the pathogenesis of the described diseases, the methods of coprological research used to diagnose intestinal helminthiases are not informative. Currently, there are parasitological, immunological, including
    James J. Plorde Helminthiasis caused by Angiostrongylus cantonensis Definition. Angiostrongylus cantonensis is a pulmonary helminth, the causative agent of the frequent form of eosinophilic meningitis found in Southeast Asia and the tropical countries of the Pacific. Etiology. Adult helminths - thin filarias (up to 20 mm long) - inhabit and lay their eggs in
  5. Clinical and epidemiological characteristics of certain types of tissue helminthiases
    Toxocarosis (Toxocarosis) - zoonotic geohelminthiasis caused by toxocar larvae, which occurs with damage to internal organs and eyes. Etiology. The causative agents of toxocariasis are the larvae of nematodes of the family Anisakidae of the genus Toxocara: Toxocara canis (a helminth that parasitizes in canines, which is most important in human pathology) and Toxocara mystax (helminth
  6. Tissue destruction and tissue hypoxia syndrome
    Ischemic stroke causes a violation of the integrity of neurons and glia, a violation of aerobic oxidation and energy homeostasis. Violation of the processes of aerobic oxidation in the brain is naturally accompanied by an increase in the concentration of lactate in the systemic circulation. Damage to the cell mass of the brain entails the release of the cytoplasmic and mitochondrial enzyme -
  7. LECTURE No. 15. Helminthiasis in children. Clinic, diagnosis, treatment, prevention
    Helminthiasis - a disease that develops when localized in the body of parasitic helminth worms and their larvae. Classification of helminthiases: 1) on the biological principle: nematodoses (roundworms), cestodoses (tape), trematodoses (flukes); 2) according to the epidemiological: geohelminthoses, biohelminthoses,
  8. Tissue hypoxia
    Distinguish between primary and secondary tissue hypoxia. Primary tissue (cellulary) hypoxia includes conditions in which primary damage to the cellular respiration apparatus occurs. The main pathogenetic factors of primary tissue hypoxia: a) a decrease in the activity of respiratory enzymes (cytochrome oxidase in case of cyanide poisoning), dehydrogenases (the effect of large doses of alcohol, urethane,
  9. Definition of tissue Po in the fetus
    The oxygen tension (Po) in the fetal tissues can be determined by the polarographic method during childbirth in the absence of the fetal bladder. This allows for early diagnosis of intrauterine hypoxia (acute and chronic) of the fetus. Intra- and percutaneous polarographic methods for determining PQ in tissues can be used. For intradermal determination of PQ, open microelectrodes are used, which
  10. Helminthiases
    Helminthiasis is a widespread disease of cats caused by parasitic worms, among which the most common are nematodes or roundworms, trematodes (flat flukes, flukes) and cestodes (tapeworms). Diseases are characterized by a chronic course leading to depletion of the body and a decrease in natural resistance. Some helminths are capable of
  11. Deafferentation and denervation hypersensitivity. Tissue deprivation. Inhibition and hyperactivity
    In clinical neurology, the origin of certain motor disorders (sensory ataxia or kinesthetic apraxia, afferent motor aphasia or cortical dysarthria) has long been known for the mechanism of deafferentation. And here, believes V.A. Karlov (1996), for a deeper understanding of the problem, it is useful to use the phylontogenetic aspect. In children, as you know, takes place
Medical portal "MedguideBook" © 2014-2019