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Injectable (prolonged) contraceptives

Injection contraception (IC) is used by more than 18 million women worldwide. The composition of the IC includes progestogens of prolonged action, devoid of estrogenic and androgenic activity:

• depot-medroxyprogesterone acetate ("Tsepo-Provera"),

• Norztisterone Enanthate ("NET-EN"). The mechanism of contraceptive action of IC:

• suppression of ovulation (inhibitory effect on the hypothalamic-pituitary system),

• changes in the physicochemical properties of the mucus of the cervical canal (its viscosity and fibrousness increase), which prevent the penetration of spermatozoa,

• violation of the level of enzymes "responsible" for the fertilization process,

• endometrial transformations that prevent implantation.

Contraceptive efficacy of IR - 0.5-1.5 pregnancies per 100 women / year. Regime use of IC: "Depo-Provera-.150" - the first dose of the drug (150 mg / 1 ampoule) is administered in the first 5 days of the menstrual cycle: subsequent injections are made every 12 weeks (3 months + 5 days); "NET-EN" - injection of the drug produced 1 time in 8 weeks (200 mg / 1 ampoule). Shake the vial before administering the IC. The drug is injected deep into the gluteus muscle. The injection area is not massaged. Restoration of fertility occurs within 4-24 months after the last injection. Indications:

• the impossibility of regular daily intake of other hormonal drugs, if desired, increase the interval between births.

• late reproductive age (over 35 years),

• contraindications to the appointment of estrogen (a number of extragenital diseases or the presence of estrogen-related complications in history),

• lactation period (6 weeks after birth),

• use as a "post-abortion" contraception.


• pregnancy

• pathological uterine bleeding of obscure genesis,

• planning pregnancy in the near future (especially in patients aged 30 to 40 years),

• malignant diseases of the reproductive organs (with the exception of endometrial cancer) and mammary glands,

• NET-EN is not acceptable during lactation. Side effects:

• violations of the menstrual cycle (especially in the first months of contraception),

• galactorrhea,

• dizziness, headache,

• fatigue,

• irritability,

• depression,

• weight gain.

• decreased libido.

Method limitations:

• violations of the menstrual cycle, especially in the first months of contraception (dysmenorrhea, acyclic uterine bleeding, oligomenorrhea, amenorrhea),

• the need for regular injections. Advantages of the method:

• high contraceptive effect,

• simplicity and confidentiality of use,

• low frequency of metabolic disorders (due to the absence of the estrogen component),

• therapeutic effects in endometriosis.
premenstrual and climacteric syndromes, dysfunctional uterine bleeding, algomenorrhea. hyperpolymeneum. endometrial hyperplastic processes. recurrent inflammatory diseases of the internal genital organs.

Recommendations to patients using the PC method: - for two weeks after the first injection of the drug to use additional contraception,

• to inject the drug every 3 months (+5 days) in a medical institution.

• if any complaints appear (especially abundant uterine bleeding, headaches, depression, weight gain, frequent urination) deserve special attention, consult a doctor,

• stop administering the drug several months before the planned pregnancy (it is necessary to take into account that fertility is restored after 4-24 months after stopping the injection of the drug),

• for prolonged amenorrhea, consult a doctor to rule out pregnancy.
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Injectable (prolonged) contraceptives

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