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Hyporegenerative anemia

Hyporegenerative anemia is not so much a nosological as a functional-morphological concept. Essentially, hyporegenerative anemia is the biological variant of any anemia. Most often, it occurs as the final stage of development of chronic post-hemorrhagic or auto-aggressive hemolytic anemia with many years of process duration, as well as due to general intoxication (azotemia, etc.), cachexia (cancerous, wound, general intoxication - alimentary, etc.) and depletion of necessary for the construction of erythrocyte substances - iron, proteins, vitamins, microelements.

Blood picture in hyporegenerative anemia is characterized by anemia of normo-hypochromic, rarely hyperchromic type with pronounced degenerative changes in erythrocytes (anisopocylocytosis), with a normal or slightly reduced white blood cell count (due to granulocytes) and a normal number of blood plates.

The bone marrow punctate is characterized by the inhibition of erythropoiesis until the almost complete disappearance of hemoglobinizing normoblasts, but with the preservation of basophilic forms of erythroblasts, which indicates a certain safety of hematopoietic reserves. There is also a disorder of granulopoiesis with delayed aging at the myelo-promyelocytic stage and impaired thrombocytopoiesis, however, the bone marrow megakaryocytes are preserved.

This form may give rise to displacement with partial bone marrow hypoplasia (see below). The peculiarity of hyporegenerative (non-hypoplastic) anemia is its reversible nature, which is proved by the positive results of therapy, both pathogenetic and etiotropic (up to the removal of the source of hidden blood loss, etc.
P.). In this regard, those states of depletion of bone marrow erythropoiesis, which are observed on the soil of long-term, blood loss, require special consideration.

We consider such conditions to be referred to as the proper hypoplastic anemia incorrect for the following reasons: 1) the primary point in the development of anemia is bleeding, therefore, according to its pathogenesis, this anemia is post-hemorrhagic; 2) unlike true hypoplastic anemias, this anemia does not have a progressive flow - it never goes into panmylophytosis; 3) the picture of bone marrow hematopoiesis corresponds more to the state of hyporegeneration (not hypoplasia): among erythroblasts, the basophilic forms predominate; therefore, there is not aplasia of the parent elements of hematopoiesis, but the depletion of iron, protein and vitamins, necessary to build mature forms of red blood; 4) despite the state of severe "dystrophy", close to hypoplasia, yet this condition is fundamentally reversible: a long and systematic complex treatment ultimately removes the bone marrow from the torpid state and brings about a practical recovery.

In view of the above, it seems more correct to consider this anemic state as chronic post hemorrhagic anemia in the r and pre-operative stage.
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Hyporegenerative anemia

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  5. Anemia due to bone marrow drainage, hypothyroidism, and aplastic anemia. MYELOPLASTIC SYNDROME
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  6. Anemia due to blood loss, post-hemorrhagic anemia
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