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Acquired hemolytic anemia

1. Immuno-hemolytic anemia

a) autoimmune

b) isoimmune

2. Acquired membranopathy

a) paroxysmal nocturnal hemoglobinuria

b) sphenocellular anemia

3. Associated with mechanical damage of red blood cells

a) marching hemoglobinuria

b) Moshkovich's disease (microangiopathic thrombocytopenia)

c) arising from prosthetic heart valves

4. Toxic

Immune hemolytic anemia is characterized by the presence in the blood of antibodies against the antigens of its own (autoimmune) or against the hapten sorbed on erythrocytes (heteroimmune). Autoimmune diseases

hemolytic anemia may be due to the presence of thermal autoantibodies, cold agglutinins. The onset of the disease is often gradual, but can also be acute, with a picture of violent hemolysis and anemic coma.

Skin pale, icteric, sometimes marked acrocyanosis.
In serum, the content of unbound bilirubin is increased. The spleen is enlarged moderately, although splenomegaly is possible. Positive direct sample Coombs.

When hemolytic anemia is caused by cold autoantibodies, the clinic of hemolytic anemia arises upon cooling. There is acrocyanosis, often acrogangrene, Raynaud's syndrome. Autoantibodies can appear when taking a number of medications.

Isoimmune hemolytic anemia can develop in newborns with the incompatibility of ABO and Rh factor of the fetus and the mother, as well as in the transfusion of incompatible blood. With these anemia, an indirect Coombs probe is positive, revealing free antibodies in the plasma.

Acquired membranopathies - Markiafawa-Micheli's disease. The disease is regarded as acquired erythrocytopathy with the appearance of an abnormal population of erythrocytes. Hemolysis is provoked by a variety of factors: the state of sleep, menstruation.
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Acquired hemolytic anemia

  1. Acquired Hemolytic Anemia
    The acquired hemolytic anemia include: • Immune hemolytic anemia; • drug hemolytic anemia; Traumatic and microangiopathic hemolytic anemia; • anemia due to the influence of hemolytic poisons, chemicals, bacterial toxins; • paroxysmal nighttime
  2. Acquired hemolytic anemia
    This is a heterogeneous group of hemolytic anemia that occurs under the influence of a number of factors that have the ability to damage erythrocytes and cause premature destruction. Classification of acquired hemolytic anemia [Idelson LI, 1975] I. Hemolytic anemia associated with exposure to antibodies. 1. Isoimmune hemolytic anemia 1) hemolytic disease of newborns
  3. Acute hemolytic anemia, conditioned by exogenous hemolytic factors
    Acute leaking hemolytic processes, accompanied by severe anemia and jaundice, arise from poisoning with hemolytic poisons of organic and inorganic origin (snake venom, mushroom poison, saponins, arsenic hydrogen, phosphorus, phenylhydrazine), with severe burns or in connection with septic, streptococcal or anaerobic infection . To hemolytic anemias of infectious nature
    Etiology and pathogenesis. In the light of modern immunohematology, the majority of acquired chronic hemolytic anemia is considered from the point of view of autoimmunization of the organism. The cause of immunization can be transferred infectious, in particular virus, diseases (influenza, pneumonia), under the influence of which autoantibodies are formed, which have specific agglutinating properties for
  5. Hemolytic anemia
    Hemolytic anemia constitute a vast group of anemic states of different etiology, the common feature of which is the pathologically increased destruction of erythrocytes. It is known that the average lifespan of erythrocytes does not exceed 100-120 days. Hemolytic anemia is characterized by a shortening of the lifespan of erythrocytes. Hemolysis can occur intracellularly or
  6. Hemolytic anemia
    Hemolytic anemia includes a vast group of anemic conditions that occur when the processes of hemorrhage predominate over the processes of hematopoiesis. The clinical picture of hemolytic anemia is very variable and depends both on the nature of the hemolytic agent and the duration of its effect on the body, and on the degree of compensation of the hemolytic process. Classification.
  7. Hemolytic anemia in children
    Hemolytic anemia - a group of anemia, characterized by hemolysis syndrome - increased destruction of erythrocytes. Erythrocytes live about 120 days, then they are destroyed - they are phagocytosed by macrophages, mainly the spleen. With hemolytic anemia, the life span of erythrocytes is significantly shortened, and when it decreases below 30 days, a hemolytic clinic
    The following groups of hereditary hemolytic anemias are distinguished: 1. Due to the violation of the structure of the erythrocyte membrane. 2. Associated with the disruption of the activity of red blood cell enzymes. 3. Associated with a disorder in the structure or synthesis of hemoglobin. Hereditary hemolytic anemias due to impaired erythrocyte membranes Hereditary hemolytic anemias associated with
  9. Hemolytic anemia
    A common symptom of hemolytic anemia is the increased destruction of erythrocytes, which, on the one hand, causes anemia and increased formation of decay products, on the other - reactively vigorous erythropoiesis. The increase in erythrocyte decay products is clinically manifested by jaundice of lemon shade, increased content of unbound (unconjugated) bilirubin in the blood, with its
    Unlike "genuine" aplastic anemia (Ehrlich type), acquired hypoaplastic anemia, especially acute forms, is caused by certain etiological factors. Of the antibiotics most often hypo-aplastic anemia causes chloromycetin (chloramphenicol, levomycetin). According to the literature, chloromycetin contains a free nitro group, which has a toxic effect. In a review work
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