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Levamisole

It is characterized by a narrow spectrum of activity. Acts only on some round helminths. It is one of the drugs of choice for the treatment of ascariasis.

Mechanism of action

The anthelmintic effect is due to a violation of the bio-energy of helminths and a paralyzing effect.

Activity spectrum

Roundworms, pinworms and some other nematodes.

Pharmacokinetics

It is well and quickly absorbed in the digestive tract. The peak concentration in the blood develops after 1.5–2 hours. It is metabolized in the liver with the formation of inactive metabolites, excreted mainly by the kidneys. The elimination half-life is 3-4 hours.

Adverse reactions

Generally well tolerated, HP develops in less than 1% of patients.

Gastrointestinal tract: abdominal pain, nausea, vomiting, diarrhea, metallic taste in the mouth, stomatitis.

Hematological reactions: more often - agranulocytosis, less often - leukopenia, thrombocytopenia.

Nervous system: peripheral polyneuropathies.

Allergic reactions: rash, etc.

Indications

Ascaridosis.

Enterobiosis.

Contraindications

Hypersensitivity to levamisole.

Pregnancy.

Lactation.

Agranulocytosis.

Warnings

Hypersensitivity.
Cross-hypersensitivity to other benzimidazole derivatives is possible.

Pregnancy. In animals, an embryotoxic effect was detected. Adequate studies of safety in humans have not been conducted. Pregnancy is not recommended.

Lactation. Adequate safety studies have not been conducted. Use during breastfeeding is not recommended.

Hematopoiesis. In patients with baseline hematopoiesis, the risk of hematotoxicity of levamisole increases. Use with caution. With agranulocytosis, the drug is contraindicated.

Drug interactions

Levamisole may enhance the effect of indirect anticoagulants of the coumarin group. It is necessary to control prothrombin time with a possible dose adjustment of anticoagulants.

Patient Information

Strictly observe the dosage regimen and treatment regimen.

Do not use expired drugs.

Observe personal hygiene.

Consult a doctor if improvement does not occur within a few days or new symptoms appear.

With enterobiosis, treatment should be carried out for all people living together.
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Levamisole

  1. NEMATODOSES
    Ascaridosis Ascaridosis is a human helminthiasis caused by the round helminth Ascaris lumbricoides. It is characterized by an allergic syndrome in the early phase of the disease and a violation of the gastrointestinal tract in the late phase. Choice of antimicrobial agents. Drugs of choice: pyrantel, 10 mg / kg once. Alternative drugs: levamisole, mebendazole, albendazole. ANKILOSTOMIDOSIS Ankylostomidosis -
  2. ANTI-HELMINTHE CHEMICAL DRUGS
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  7. Ascaridosis.
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  12. TREATMENT
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