Licensed books on medicine
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| Levamisole
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It is characterized by a narrow spectrum of activity. Acts only on some round helminths. It is one of the drugs of choice for the treatment of ascariasis.
Mechanism of action
The anthelmintic effect is due to a violation of the bio-energy of helminths and a paralyzing effect.
Activity spectrum
Roundworms, pinworms and some other nematodes.
Pharmacokinetics
It is well and quickly absorbed in the digestive tract. The peak concentration in the blood develops after 1.5–2 hours. It is metabolized in the liver with the formation of inactive metabolites, excreted mainly by the kidneys. The elimination half-life is 3-4 hours.
Adverse reactions
Generally well tolerated, HP develops in less than 1% of patients.
Gastrointestinal tract: abdominal pain, nausea, vomiting, diarrhea, metallic taste in the mouth, stomatitis.
Hematological reactions: more often - agranulocytosis, less often - leukopenia, thrombocytopenia.
Nervous system: peripheral polyneuropathies.
Allergic reactions: rash, etc.
Indications
Ascaridosis.
Enterobiosis.
Contraindications
Hypersensitivity to levamisole.
Pregnancy.
Lactation.
Agranulocytosis.
Warnings
Hypersensitivity.
Cross-hypersensitivity to other benzimidazole derivatives is possible.
Pregnancy. In animals, an embryotoxic effect was detected. Adequate studies of safety in humans have not been conducted. Pregnancy is not recommended.
Lactation. Adequate safety studies have not been conducted. Use during breastfeeding is not recommended.
Hematopoiesis. In patients with baseline hematopoiesis, the risk of hematotoxicity of levamisole increases. Use with caution. With agranulocytosis, the drug is contraindicated.
Drug interactions
Levamisole may enhance the effect of indirect anticoagulants of the coumarin group. It is necessary to control prothrombin time with a possible dose adjustment of anticoagulants.
Patient Information
Strictly observe the dosage regimen and treatment regimen.
Do not use expired drugs.
Observe personal hygiene.
Consult a doctor if improvement does not occur within a few days or new symptoms appear.
With enterobiosis, treatment should be carried out for all people living together. | | << Previous | | Next >> | | = Skip to textbook content = |
| Levamisole
| - NEMATODOSES
Ascaridosis Ascaridosis is a human helminthiasis caused by the round helminth Ascaris lumbricoides. It is characterized by an allergic syndrome in the early phase of the disease and a violation of the gastrointestinal tract in the late phase. Choice of antimicrobial agents. Drugs of choice: pyrantel, 10 mg / kg once. Alternative drugs: levamisole, mebendazole, albendazole. ANKILOSTOMIDOSIS Ankylostomidosis -
- ANTI-HELMINTHE CHEMICAL DRUGS
Anthelmintic drugs are used for helminthiases - diseases (invasions) of varying severity caused by parasitic worms - helminths. In recent years, the arsenal of the most clinically significant anthelmintic drugs has decreased, and therefore their traditional classification, built on the principle of action on certain types of helminths (round - nematodes; tape -
- Subject: Immunoprophylaxis, immunotherapy and immunocorrection
The development of the doctrine of immunoprophylaxis and immunotherapy. E. Jenner, L. Pasteur, E. Bering, G. Ramon and others. Principles of immunization. Drugs for immunization: vaccines, serums, immunoglobulins. The current classification of vaccines (live, inactivated, molecular, synthetic, anti-idiotypic). Methods of preparation, evaluation of effectiveness and control. Associated vaccines.
- Systemic lupus erythematosus
Systemic lupus erythematosus (SLE): A nonspecific autoimmune disease of the body that is accompanied by lesions caused by cytotoxic antibodies and the deposition of immune complexes. SLE is observed in many species of mammals (human, mouse, monkey, cat, dog and horse). As a rule, the disease proceeds in a subacute or - more often - in a chronic form, accompanied by
- Treatment
Acute, subacute and chronic brucellosis in the stage of decompensation are treated in a hospital, the remaining forms are outpatient (i.e. subcompensated forms). Antibiotic therapy, anti-inflammatory therapy, desensitizing therapy and symptomatic therapy are carried out. Etiotropic therapy is carried out for at least 4 weeks. Schemes: tetracycline 0.3 4 times a day streptomycin 0.5 2 times a day
- Mebendazole
It has structural similarities with levamisole, but has a slightly wider spectrum of activity. The mechanism of action The anthelmintic effect is due to a violation of the synthesis of cell tubulin, glucose utilization and inhibition of ATP formation. The activity spectrum of roundworm, pinworm, hookworm, whipworm, trichinella and a number of other nematodes. The larval stages of some cestodes (echinococcus,
- Ascaridosis.
The causative agent is roundworm. The transmission path is feck-op. Anthroponosis, geohelmintosis - for the maturation of eggs, their stay in the soil at 24 ° C is necessary. Pathogenesis. Eggs enter the intestine, larvae are hatched, which enter the portal vein through the wall of the intestine, then into the liver (by the 5th day). By the 10th day - hematogenously into the lungs, where they molt 2 times, break through the wall of the alveoli and through the respiratory tract
- Hookworm (hookworm and necatorosis)
Etiology, pathogenesis. The causative agents - hookworm and nekator, parasitize in the small intestine of a person, more often - in the duodenum. Infection occurs when the larvae penetrate the skin or if the larvae are swallowed with contaminated fruits, vegetables, and water. Larvae migrate along the large and small circle of blood circulation for about 7-10 days. In the small intestine, they become sexually mature individuals and
- Vizer V.A .. Lectures on therapy, 2011
On the subject - almost completely cover the difficulties in the course of hospital therapy, the issues of diagnosis, treatment, as stated, are concise and quite affordable. Allergic lung diseases Joint diseases Reiter's disease Sjogren's disease Bronchial asthma Bronchiectasis Hypertension Glomerulonephrosafasdit Esophageal hernia Destructive lung diseases
- ALLERGIC LUNG DISEASES
In recent decades, a significant increase in the number. patients with allergic diseases of the bronchopulmonary apparatus. Allergic lung diseases include exogenous allergic alveolitis, pulmonary eosinophilia, and drug
- EXOGENOUS ALLERGIC ALVEOLITES
Exogenous allergic alveolitis (synonym: hypersensitive pneumonitis, interstitial granulomatous alveolitis) is a group of diseases caused by intensive and, more rarely, prolonged inhalation of antigens of organic and inorganic dusts and are characterized by diffuse, in contrast to pulmonary eosinophilia, lesions of the alveolar and interstitial structures of the lungs. The emergence of this group
- TREATMENT
1. General measures aimed at disconnecting the patient from the source of antigen: compliance with sanitary and hygienic requirements at the workplace, technological improvement of industrial and agricultural production, rational employment of patients. 2. Drug treatment. In the acute stage, prednisone 1 mg / kg per day for 1-3 days, followed by a dose reduction in
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