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Comparative evaluation of various methods
To evaluate the methodological problems of non-invasive registration of late ventricular potentials, a comparative study was conducted on the basis of several scientific centers . In the same group of 109 patients (80 with coronary heart disease and 29 with dilated cardiomyopathy), various registration systems were compared; in two of them, the Princeton 4202 signal averager (methods A and B) was used [14, 39], in one, the Marquette MAC I signal averager (method B), and in the latter, a computer-aided digital signal averaging system developed by Simson  ( method D). The study in each patient by all 4 methods lasted no more than 2 hours. The main difference between methods A and B was that with method A, late potentials were taken into account only if they were determined at the end of the QRS complex in standard ECG leads.
Late ventricular potentials were recorded by method A in 12% of patients, method B in 21%, method B in 14% and method G in 20%.
Compliance was positive in 6% of cases and negative in 69% of cases. Differences in results when compared with three other methods are noted for method D in 12 cases, method B in 5 cases and method A in 2 cases. In 10% of patients, the results of the two methods were the same. Despite the differences in the results obtained by different methods, a detailed analysis of the ECG of patients with conflicting data showed that these differences (mainly between methods A, B and C) are due to differences in visual assessment. Methods that do not take into account the duration of the QRS complex (methods B and D) gave a greater number of positive results than methods using this value (methods A and C). Further prospective studies should show whether it is possible to detect delayed depolarization in the final part of the QRS complex or whether its determination after the end of the QRS complex is predictive only.
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Comparative evaluation of various methods
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