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EFFECTIVENESS OF EPREX AND ARANESP IN TREATMENT OF ANEMIA INDUCED CHEMOTHERAPY

Snegovoy A.V., Manzyuk L.V., Osmanova L.I.

Russian Oncology Center named after N.N. Blokhin RAMS, Moscow

Research objectives: To evaluate the effectiveness of epoetins in anemia-induced chemotherapy.

Materials and research methods: 29 patients receiving chemotherapy for various malignant tumors were included. Severe anemia with baseline hemoglobin (Hb) levels below 8 g / dl was observed in 4 (14%), moderate anemia (Hb <10> 8 g ​​/ dl) in 25 patients (80%). Before starting treatment, all patients have determined the serum concentration of total iron, the degree of saturation of transferrin, C-reactive protein, folate, vitamin B12 and the iron-binding ability of blood serum. Eprex was administered subcutaneously at a dose of 150 IU / kg body weight 3 times a week or at a dose of 450 IU / kg body weight 1 time per week (16 patients).
Aranesp was administered at 500 mcg - once every 3 weeks subcutaneously (13 patients). In 41% of cases (12 patients), an additional appointment of iron (Venofer) was required.

Results: 8 out of 16 patients (50%) treated with Eprex achieved the target Hb level within 16 weeks of therapy. 7 patients out of 13 (54%) treated with Aranesp achieved the target Hb value at different times: in 8 weeks - 2, in 12 weeks - 2, in 16 weeks - 3 patients. The overall efficacy of epoetins was 51% (15/29). Of the complications, thrombophlebitis of superficial veins of the lower extremities was noted in 2 patients (6.8%).

Conclusion: Epoetins (Eprex, Aranesp) make it possible to increase Hb levels in 50% of patients with anemia-induced chemotherapy.
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EFFECTIVENESS OF EPREX AND ARANESP IN TREATMENT OF ANEMIA INDUCED CHEMOTHERAPY

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