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EFFICACY OF EPREX AND ARANESP IN TREATING ANEMIA BY INDUCED CHEMOTHERAPY
Snegovoi A.V., Manzyuk L.V., Osmanova L.I.
RCRC im.N.Blokhina RAMS, Moscow
Objectives of the study: To evaluate the effectiveness of epoetins in anemia induced by chemotherapy.
Materials and methods: Included 29 patients receiving chemotherapy for various malignant tumors. Severe anemia with baseline hemoglobin (Hb) levels below 8 g / dl was observed in 4 (14%), moderate anemia (Hb <10> 8 g / dl) in 25 patients (80%). Before treatment, all patients determined the serum concentration of total iron, the degree of saturation of transferrin, C-reactive protein, folate, vitamin B12 and the iron-binding capacity of the blood serum. Eprex was administered subcutaneously at a dose of 150 IU / kg body weight 3 times a week or at a dose of 450 IU / kg body weight 1 time per week (16 patients).
Aranesp was administered at 500 mcg - 1 time per 3 weeks subcutaneously (13 patients). In 41% of cases (12 patients) an additional administration of iron was required (Venofer).
Results: 8 patients out of 16 (50%) who received Eprex reached the target Hb level within 16 weeks of therapy. 7 patients out of 13 (54%) who received Aranesp achieved the target Hb value at various times: for 8 weeks - 2, for 12 weeks - 2, for 16 weeks - 3 patients. The overall effectiveness of epoetins was 51% (15/29). Of the complications, thrombophlebitis of the superficial veins of the lower extremities was noted in 2 patients (6.8%).
Conclusion: Epoetins (Eprex, Aranesp) allow to increase the level of Hb in 50% of patients with anemia induced by chemotherapy.
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EFFICACY OF EPREX AND ARANESP IN TREATING ANEMIA BY INDUCED CHEMOTHERAPY
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