Licensed books on medicine
<< Previous || Next >> |
EFFECTIVENESS OF EPREX AND ARANESP IN TREATMENT OF ANEMIA INDUCED CHEMOTHERAPY
Snegovoy A.V., Manzyuk L.V., Osmanova L.I.
Russian Oncology Center named after N.N. Blokhin RAMS, Moscow
Research objectives: To evaluate the effectiveness of epoetins in anemia-induced chemotherapy.
Materials and research methods: 29 patients receiving chemotherapy for various malignant tumors were included. Severe anemia with baseline hemoglobin (Hb) levels below 8 g / dl was observed in 4 (14%), moderate anemia (Hb <10> 8 g / dl) in 25 patients (80%). Before starting treatment, all patients have determined the serum concentration of total iron, the degree of saturation of transferrin, C-reactive protein, folate, vitamin B12 and the iron-binding ability of blood serum. Eprex was administered subcutaneously at a dose of 150 IU / kg body weight 3 times a week or at a dose of 450 IU / kg body weight 1 time per week (16 patients).
Aranesp was administered at 500 mcg - once every 3 weeks subcutaneously (13 patients). In 41% of cases (12 patients), an additional appointment of iron (Venofer) was required.
Results: 8 out of 16 patients (50%) treated with Eprex achieved the target Hb level within 16 weeks of therapy. 7 patients out of 13 (54%) treated with Aranesp achieved the target Hb value at different times: in 8 weeks - 2, in 12 weeks - 2, in 16 weeks - 3 patients. The overall efficacy of epoetins was 51% (15/29). Of the complications, thrombophlebitis of superficial veins of the lower extremities was noted in 2 patients (6.8%).
Conclusion: Epoetins (Eprex, Aranesp) make it possible to increase Hb levels in 50% of patients with anemia-induced chemotherapy.
| << Previous || Next >> |
| = Skip to textbook content = |
EFFECTIVENESS OF EPREX AND ARANESP IN TREATMENT OF ANEMIA INDUCED CHEMOTHERAPY
- Prevention and treatment of “cytokine-induced” vasculitis
To reduce the damaging effect of inflammatory mediators on the capillary endothelium already in the first hours of treatment it is shown: 1. The use of glucocorticoids that inhibit the activity of phospholipase A, which reduces the formation of arachidonic acid from phospholipids of cell membranes damaged by hypoxia. Dosadexazone is 40-60 mg, for prednisone, 300-450 mg per day in a decreasing dose over
- HYPERTHERMIA IN COMBINATION WITH RADIATION THERAPY AND CHEMOTHERAPY FOR TREATMENT OF CANCER. NEW MANY PROMISING THERAPY
HYPERTHERMIA IN COMBINATION WITH RADIATION THERAPY AND CHEMOTHERAPY FOR TREATMENT OF CANCER. NEW MANY PROMISING
- The study of the effectiveness of the use of Dietrim and Vetom 1.1. in the treatment of rabbit coccidiosis
Sarapkina A.A., Galiakhmetov O.K. Scientific adviser - associate professor Gizatulina S.R. Federal State Educational Institution of Higher Professional Education “Ural State Academy of Veterinary Medicine”, Troitsk. Coccidiosis (eimeriosis) is the most common rabies protozoal disease, causing significant damage to rabbit breeding. The invasion of young animals can reach 70-00%. Rabbit emeriosis is widespread throughout
- EFFECTIVENESS OF 2-ZONAL LYMPHODISSECTION IN SURGICAL TREATMENT OF PATIENTS WITH CANCER OF THE ESOPHESOPULA III - IV STAGE
Kulikov E.P1., Kaminsky Yu.D1,2., Karpov D.V1., Ryazantsev M.E2., Vinogradov I.Yu2. 1 Department of Oncology, Ryaz. State Medical University named after Acad. I.P. Pavlova; 2 Ryazan Regional Clinical Oncology Center Research objective: To assess the feasibility of performing 2-zone lymphatic dissection (LD) in the surgical treatment of patients with locally advanced (T4) and metastatic (M1) esophageal cancer (RP)
- TWO CHEMOTHERAPY PROGRAMS IN COMBINATION WITH BEVACISUMAB IN TREATMENT OF DISSEMINATED COLORECTAL CANCER
Zharkova O.V.1, Mironova E.B.3, Karaseva V.V.2, Khailenko V.A.2, Kadnikova O.D.3, Feoktistova P.S. 4, Sizintsev A.V.1, Kolesnikov Ya.M.1 GUZ OKOD, Kemerovo1 Russian State Medical University, Moscow2 KB No. 81 of the FMBA of Russia, Seversk3 OD, Nizhnevartovsk4 Research Objective: To study the effectiveness and toxicity of bevacizumab in combination with two chemotherapy programs in patients with metastatic forms
- ANEMIA UNDER CONDITIONS OF FUNCTIONAL AGASTRIA (AGRICULTURAL ANEMIA)
In contrast to the actual agastric anemia associated with partial or complete anatomical removal of the stomach, we distinguish anemia that develops in conditions of functional agastria, when the anatomically preserved stomach is partially or completely turned off from the physiological digestion process and, in particular, loses the ability to assimilate the external antianemic factor - vitamin B12.
- COMPARISON OF EFFECTIVENESS OF ALPHA AND BETA EPOETIN FOR ANEMIA CORRECTION IN PATIENTS WITH LYMPHO-PROLIFERATIVE DISEASES
Romanenko N.A., Abdulkadyrov K.M. Federal State Institution Russian Research Institute of Hematology and Transfusiology, Federal Medical and Biological Agency of Russia, St. Petersburg Objective: To study the effectiveness of EPO alpha and beta in patients with lymphoproliferative diseases (LPS) for the correction of anemia and compare the effectiveness of recombinant erythropoietin
- Intra-peritoneal chemotherapy for disseminated rectal cancer
Porunov V.Yu., Igitov V.I., Lazarev A.F., Mamontov G.K., Belonozhka A.V., Lazarev S.A., Elinov A.P., Kovrigin A.O. AF RONTs im.N.N. Blokhin RAMS, Barnaul Objective: To assess the effectiveness of using intraperitoneal chemotherapy for disseminated rectal cancer with lesions of the peritoneum. Material and methods: Intraperitoneal administration for 71 patients in the coloproctology department of the GUZ AKOD
- CHEMOTHERAPY FOR INFECTIOUS DISEASES
Harold C. New (Harold C. Neu) Introduction. There are many reasons for using a very large number of new antibacterial drugs in practice. The most important of these include changes in the macroorganism, the emergence of new pathogens and their drug resistance to antibacterial drugs. Under the changes in the macroorganism mean the long-term experience of patients,
- NEOADJUVANT INTRA-ARTERIAL CHEMOTHERAPY IN COLORECTAL CANCER WITH LIVER METASTASES
Elinov A.P., Mamontov K.G., Lazarev A.F., Kotelnikov A.G., Igitov V.I., Lazarev S.A., Belonozhka A.V. AF GU RONTs im.N.N. Blokhin RAMS, Barnaul Objective: To study the effectiveness of the use of neoadjuvant chemotherapy as a component of the complex treatment of patients with colorectal cancer with liver metastases. Material and methods: We have experience of 92 intra-arterial infusions in 52 patients
- Acute renal failure during chemotherapy
1. What medications most commonly cause kidney failure? Dysplatin, piroxicam, and methotrexate. There is evidence that doxorubicin leads to kidney disease in cats and dogs. In addition, tumor processes themselves, in particular transitional cell carcinoma, can become the cause of renal failure. 2. How does cisplatin cause kidney failure? The most
- Treatment Efficiency Criteria
To assess the effectiveness of preventive treatment for symptomatic paroxysmal tachycardia, one can focus on the patient's feelings. In this case, a follow-up period is required that exceeds the maximum interval between tachycardia attacks by at least 3 times. The results of treatment of frequent daily tachycardia paroxysms can be assessed by daily monitoring of ECG by
- The effectiveness of the treatment and rehabilitation of patients with cerebral palsy
Older authors wrote that the treatment of cerebral palsy is “little fruitful” (M.O. Gurevich, 1937). After more than 60 years, the situation has not actually changed. I.A. Zavalishin and V.P. Barkhatova (1997) in their review of the problem of spasticity bitterly state that the treatment of paresis is still an almost insoluble task. According to these authors, despite significant successes, neurochemical and pathophysiological
- TREATMENT EFFICIENCY CRITERIA
lack of clinical signs, • normalization of laboratory parameters • PC (hemoglobin, red blood cells, reticulocytes) and • biochemical blood analysis (bilirubin, free plasma hemoglobin), • absence