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Pathological physiology


A.V. Pasechnik, E.G. Moiseeva, V.A. Frolov, G.A. Drozdov Inflammation and metabolic disorders 2011
Treatment of inflammatory periodontal diseases reduces the levels of such cardiovascular risk factors as C-reactive protein and fibrinogen, established by American scientists. This is another proof of the connection between periodontal diseases and cardiovascular pathology. C-reactive protein (CRP) and fibrinogen are acute-phase proteins and systemic markers of inflammation.

As stated at the 82nd General Session of the International Association for Dental Research (Honolulu, Hawaii, USA), complex treatment led to a significant decrease in the initially elevated concentrations of CRP (at least 3 mg / l) and fibrinogen (at least 3 g / l). The concentration of CRP and fibrinogen decreased by 9 months with only mechanical treatment, and by 6 months with the additional prescription of an antibacterial drug (p <0.05).

Thus, in patients with elevated CRP levels, removal of dental plaque bacteria in combination with local antibiotic therapy reduced the CRP concentration to characteristic figures for low cardiovascular risk.

Today, we and many other authors are developing the effects of complex therapy on the levels of other inflammatory markers - cytokines, including the effects on metabolic proatherogenic parameters.

For students, clinical interns and graduate students of medical faculty, students in the specialties "Dentistry", "General Medicine"
Toolkit Hypoxia 2010
Definition of the concept, types of hypoxia. Etiology and pathogenesis of various types of hypoxia. Compensatory-adaptive reactions. Violations of the basic physiological functions and metabolism. Mechanisms of hypoxic necrobiosis. Disbarism. Adaptation to hypoxia and disadaptation
Toolkit Pathological physiology of the endocrine system 2010
General characteristics of the endocrine system. The main manifestations of endocrine disorders. The main etiological factors and pathogenetic mechanisms of endocrine pathology. Disturbance of the central mechanisms of endocrine function regulation (central damage level). Ways of central regulation of vegetative functions. Pathological processes in the gland itself. Peripheral (extra iron) mechanisms of hormonal activity disorders. Intrauterine endocrinopathy. Compensatory-adaptive mechanisms. The role of endocrine disorders in the pathogenesis of non-endocrine diseases. Principles of treatment and prevention of endocrine disorders.
Leonova E.V. Chanturia A.V. Vismont F.I. Pathological physiology of the blood system 2009
Blood is an extremely complex, especially vital system, which largely determines the integrity of the organism. For a doctor of any specialty it is necessary to know the basics of hematology. The pathophysiological aspects of blood disorders for the clinician are essential. This issue is devoted to this manual. It includes the current information about blood, violation of erythro- processes, leukopenia, trombotsitopoeza of pathology of hemostasis-antigemostaza of standard forms and reactive changes in the erythrocyte system, white blood cells, platelets, hemostasis, antigemostaza, as well as issues related to the etiology, pathogenesis, changes blood in the most common types of anemia, erythrocytosis, leukemia, hemostasiopathy.

The expediency of publishing this manual is due to the rapid development of hematology, enriching it with new achievements and ideas that have not been adequately reflected in educational literature, the need to present them in a form accessible to students.

The purpose of the classes is to study the causes and mechanisms of disorders of the processes of erythro, leuco-, thrombocytopoiesis, hemostasis-antihemostase; typical changes in blood cells, etiology, pathogenesis of various types of anemia, erythrocytosis, leukemia, hemostasiopathy; changes in their blood picture.

The tasks of the classes - the student must: ……
Toolkit Pathology of external respiration 2009
Regulation of breathing. Dysfunction of the respiratory center. Forms of violation of DC activity. Typical disorders of gas exchange lung function. Violation of alveolar ventilation. Types of hypoventilation disorders. Violations of ventilation and perfusion relationships. Violation of the diffusion capacity of the lungs. Pathological types of respiration. Terminal types of respiration. Dissociated breath. Dyspnea. Etiology, pathogenesis, effects of cough. Lack of external respiration.
Yu.I. Kosyuga, V.A. Lyalyaev, ON Shevantaeva Fever and hyperthermia 2009
Methodical instructions for independent work of students of the faculty of higher education (extramural studies)

Fever and hyperthermia. Etiology of fever. Pathogenesis of fever. Stage fever. Classification of fever. The value of temperature curves in fever. Changes in organs and systems during fever. The value of fever. Hyperthermia. Classification. Differences from fever. Endogenous hyperthermia. Exogenous hyperthermia. Questions for self-control knowledge on the topic of "Fever and hyperthermia"
Tutorial Pathophysiology of the kidneys 2008
The “Teaching aid” presents in detail a theoretical block of information, where the fundamental material on the pathophysiology of the kidneys, as well as test tasks with standard answers to them and situational tasks are presented. The materials are intended for students of medical institutes and universities of biomedical profile, may be useful to residents, graduate students, subordinators and nephrologists, including self-control.
Tutorial Typical pathological processes. Pathophysiology of metabolism. 2008
The manual contains educational material for the most important section - the pathophysiology of metabolic curriculum discipline "Pathophysiology". In the process of learning, students are faced with the need to integrate knowledge gained from studying metabolism in academic disciplines in biochemistry, physiology, pathological anatomy, pathophysiology, and the development of skills in applied clinical thinking. The objective of this textbook is to teach a student a clinical and pathophysiological understanding of the knowledge gained from studying this section of pathology for subsequent use in clinical disciplines. In the process of independent work, students get the opportunity to get acquainted with the generalized material of textbooks, in-depth information from additional sources. To facilitate the development of this knowledge, algorithms for the causes, mechanisms and manifestations of metabolic disorders in the form of tables and diagrams are presented. On the example of test tasks, it is possible to analyze and fix the obtained information. Situational tasks allow developing clinical and pathophysiological thinking and differential diagnosis skills. The manual is intended for students of medical schools, it may be useful for interns, clinical residents, graduate students and medical practitioners.
Toolkit Oral pathology 2007
Pathology of the oral cavity. General characteristics. Inflammatory diseases of the oral mucosa. Diseases of the oral cavity. Diseases of the teeth. Inflammatory diseases of the maxillofacial apparatus. Features of their occurrence and course. The role of local hypoxia in the pathogenesis of inflammatory and dystrophic lesions of the tissues of the maxillofacial region. Malformations of the maxillofacial apparatus. The role of genetic factors in their development. Tumors of the oral cavity. Pathology of the oral cavity and digestive disorders. Impaired digestion in the mouth. The role of dental disorders in disorders of the gastrointestinal tract. The role of chronic inflammatory processes of the oral cavity in the formation of pathological immune reactivity. The main manifestations in the oral cavity are blood pathologies. The main manifestations in the oral cavity are chronic insufficiency of the cardiovascular system. The main manifestations in the oral cavity are pathologies of the liver and gastrointestinal tract. The main manifestations in the oral cavity are renal pathology, an insular apparatus. Communication of respiratory disorders and pathology of oral tissues. The main manifestations in the oral cavity of phosphorus-calcium metabolism. The role of hormonal disorders in the formation of the pathology of the dental system, their manifestations in the oral cavity. The main manifestations in the oral cavity are chronic intoxication with heavy metals.
Toolkit Situational task bank 2007
State educational institution of higher professional education "Krasnoyarsk State Medical Academy of the Federal Agency for Health and Social Development" (GOU VPO KrasGMA of Roszdrav). Faculty of Medicine 3 course.
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