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Dizerythropoietic anemia (due to impaired erythropoiesis)

This group of diseases includes:

a) anemia, combined by a common mechanism of occurrence associated with the violation or termination of erythropoiesis as a result of a deficiency of substances necessary for normal blood formation - deficient anemia (B12 -, B6 -, B2 - folic-deficient, iron-copper-cobalt-deficient, protein deficiencies), as well as anemia, arising from the inability of the bone marrow to absorb hemopoietic factors — achrestic anemias (sideroachrestrial, B12 –archastic, etc.);

b) anemia caused by damage to the bone marrow toxic and medicinal substances, ionizing radiation (hypo-and aplastic anemia);

c) anemia in leukemia, metastasis of tumors to the bone marrow (metaplastic anemia).
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Dizerythropoietic anemia (due to impaired erythropoiesis)

  1. Anemia due to impaired hemoptosis
    DEFINITION Diamond-Blackfan Anemia is a group of congenital red cell aplasias that are usually diagnosed during the first year of life. EPIDEMIOLOGY Currently, hemolytic anemia due to vitamin E deficiency has largely disappeared due to the improved composition of mixtures for premature newborns containing lower concentrations of polyunsaturated fatty acids
  2. Hereditary dimeritropoeticheskie anemia
    Under dizeritroezom understand the pathologically changed ratio of the processes of proliferation and maturation of erythroid cells in the bone marrow. Hereditary (congenital) dyseritropoietic anemia (ACA) are rare forms of anemia in which characteristic morphological anomalies are found in the bone marrow, and not in peripheral blood, although there are also non-specific morphological changes.
  3. ANEMIA DUE TO TOXIC EXPOSURE OF THE BONE MARROW (MYETHOXICAL ANEMIA)
    THYROORTHEUS ANEMIA Thyroid stimulation anemia is anemia that develops on the basis of hypothyroidism. Experimental work confirms the important role of thyroid hormone - thyroxin - in stimulating normal blood formation. Animals deprived of the thyroid gland, quickly anemiziruyutsya, the introduction of the same thyroid drugs to thyroidectomized animals cures them from the effects of thyroid-induced
  4. Anemia due to blood loss, post-hemorrhagic anemia
    Anemia due to blood loss, post-haemorrhagic
  5. Anemia due to bone marrow drainage, hypothyroidism, and aplastic anemia. MYELOPLASTIC SYNDROME
    Despite the large number of studies devoted to the study of hypo-and aplastic anemias, it is still not possible to create a rational classification of these conditions, since not only the issues of pathomorphogenesis, but even the definition of the very concept of "hypo (a) plastic anemia" is debatable. In accordance with modern concepts of the genesis of hypo- and
  6. Anemia associated with impaired synthesis of DNA and RNA (megaloblastic anemia)
    Megaloblastic anemia unites a group of acquired and hereditary anemias, a common feature of which is the presence of megaloblasts in the bone marrow. Regardless of the etiology of the patients, hyperchromic anemia with characteristic changes in the erythrocyte morphology is revealed - oval red blood cells, large (up to 12-14 microns or more). There are red blood cells with basophilic cytoplasm, in many of
  7. Anemia associated with impaired synthesis or utilization of porphyrins (sideroachrestic, sideroblastic anemia)
    This is a heterogeneous group of diseases, hereditary and acquired, associated with a violation of the activity of enzymes involved in the synthesis of porphyrins and heme. The term "sideroahresticheskaya anemia" was introduced by Iewer (1957). In case of sideroachrestric anemia, serum iron levels are elevated. In the bone marrow detect ring-shaped sideroblasts - nucleated red blood cells with a nucleolus corolla,
  8. Strangulation asphyxia (hanging) - ONE due to airway obstruction
    Hanging in most cases - suicide, committed while intoxicated. The main etiological factor in hanging is mechanical asphyxiation (asphyxiation). The trachea, the large vessels supplying blood to the brain, and the vessels through which blood flows from the head are compressed. The severity of the condition depends on the length of stay in the loop and the location of the loop.
  9. HEMOLYTIC ANEMIA CAUSED BY DISTURBANCE OF HEMOGLOBIN SYNTHESIS
    This group of hemolytic anemia includes two main subgroups: • thalassemia - hereditary hemolytic anemia, caused by a violation of the synthesis of one or more globin polypeptide chains (“quantitative” hemoglobinopathy); • hemoglobinopathies - hereditary hemolytic anemias due to changes in the primary structure of the polypeptide chains of globin, which leads to
  10. Erythropoiesis
    Human erythroid cells consist of the following classes: I - the parental hematopoietic cell; II is a precursor cell of myelopoiesis; III - unipotent progenitor cells of erythropoiesis, poetically sensitive; IV - erythroblasts; V - mature cells: pronomocyte; normocyte basophilic, polychromatophilic, oxyphilic, reticulocyte; VI - red blood cell. Currently
  11. Hereditary hemolytic anemia caused by the disturbance of the activity of red blood cell enzymes
    Fermentopathies or non-spherocytic hemolytic anemias are characterized by a hereditary decrease in activity or instability of erythrocyte enzymes. Inherited autosomal recessive or X-linked recessive type. The most severe hemolytic manifestations are observed, as a rule, in homozygous carriers with an almost complete absence of enzyme activity in
  12. Erythropoiesis
    Erythropoiesis is a process of structural, metabolic and functional differentiation, starting from the formation of a polypotent stem cell and ending with the formation of a mature erythrocyte. There are megalo-and erythroblastic types of blood formation. Megaloblastic erythropoiesis is as follows. In the process of cell maturation, hemoglobin (Hb) gradually accumulates in their cytoplasm,
  13. ANEMIA CAUSED BY DISTURBANCE OF THE STRUCTURE OF LIPID MEMBRANE OF ERYTHROCYTES
    Hereditary acanthocytosis Hereditary acanthocytosis is a heterogeneous group of hereditary hemolytic anemias characterized by erythrocyte membrane lipids and the appearance of acanthocytes in the peripheral blood. Acanthocytosis is acquired (with neurogenic anorexia, hypothyroidism, liver disease, vitamin E deficiency, etc.) and congenital. Characteristic sign of acanthocytosis
  14. Hereditary hemolytic anemia associated with impaired structure or hemoglobin synthesis (hemoglobinopathy)
    Hemoglobinopathies are hereditary anomalies of human hemoglobin synthesis, manifested either by changes in the primary structure of the hemoglobin molecule (“qualitative” hemoglobinopathies), or a violation of the ratio or lack of synthesis of one of the globin chains with an unchanged primary structure (“quantitative” hemoglobinopathies). Hemoglobinopathies are inherited autosomal dominantly,
  15. Hereditary hemolytic anemia associated with erythrocyte membrane abnormality (membranopathy)
    Membranopathies are characterized by a hereditarily caused defect in the structure of the protein of the membrane or in violation of the lipids of the erythrocyte membrane. Autosomal dominant or augosomal recessive are inherited. Hemolysis is localized, as a rule, intracellularly, that is, the destruction of red blood cells occurs mainly in the spleen, to a lesser extent - in the liver. Classification of hemolytic anemia related
  16. ANEMIA CAUSED BY DISTURBANCE OF THE STRUCTURE OF THE PROTEIN OF ERYTHROCYTE MEMBRANE
    Structure and function of the erythrocyte membrane The erythrocyte membrane is a double lipid layer containing protein structures. Lipids in the erythrocyte membrane are represented by phospholipids and free cholesterol in approximately the same molar ratios. In the erythrocyte membrane, there are 4 main classes of phospholipids - phosphatidylcholine, phosphatidylethanolamine,
  17. General characteristics of hematopoiesis. Erythropoiesis. Erythrocyte morphology, kinetics, functions
    Hematopoietic tissue is formed already in the early stages of human embryogenesis. Hematopoiesis begins in the yolk sac at the 3rd week of human embryo development. At this stage, blood formation is reduced mainly to erythropoiesis. The formation of primary erythroblasts occurs inside the vessels of the yolk sac. Primitive erythroblasts are large nucleated round cells. By the end of the 6th
  18. ANEMIA UNDER CONDITIONS OF FUNCTIONAL AGASTRY (AGASTRAL ANEMIA)
    In contrast to the actual agastric anemia associated with partial or complete anatomical removal of the stomach, we distinguish anemia that develops in conditions of functional agastria, when the anatomically preserved stomach partially or completely turns off from the physiological process of digestion and, in particular, loses the ability to assimilate the external antianemic factor - Vitamin B12.
  19. Hyperkalemia due to decreased renal excretion of potassium
    Reduced renal excretion of potassium occurs in the following cases: (1) a pronounced decrease in glomerular filtration rate; (2) a decrease in aldosterone activity; or (3) a violation of potassium secretion in the distal nephron. When the glomerular filtration rate is less than 5 ml / min, hyperkalemia almost always occurs. Against the background of high potassium load (alimentary, metabolic or iatrogenic
  20. Ventricular arrhythmia due to exercise
    Ventricular arrhythmia due to physical
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