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Neuro-trophic effects and alternative processes in inflammation
According to existing ideas, in the process of alteration in the focus of inflammation, two types of phenomena can be observed, differing in the nature of changes in the nervous regulation of tissue and the value in the activity of cells. As a result of direct and indirect (circulatory disorders, hypoxia, acidosis, enzymatic processes) damage to the receptors of conductors and neurons, as well as their synaptic contacts (pre- and postsynaptic formations), “denervation” is formed, more precisely, a kind of functional and structural isolation of damaged tissue from nerve influences. Although this phenomenon occurs due to tissue damage, it prevents the arrival of intense, including pain, signals from their focus of inflammation and limits the effects of neurotransmitters, intensely released in violation of the integrity of nerve endings. Such changes in the nervous regulation of cells are most characteristic of a zone of pronounced alteration, localized in the center of the focus of inflammation. In the dynamics of inflammation in the peripheral zone, the activity of the nerve apparatus is preserved, they are irritated and various local trophic reflexes, axon reflexes, and reflexes that are closed at different levels of the central nervous system are formed. It is in this zone of reactive tissue changes that the CNS, its various levels, as well as endocrine and other systems, are manifested.
The occurrence of phenomena that are different in their regulation in tissue during inflammation explains the very pronounced differences in the results of studying the effect of denervation on local signs of inflammation.
It is known that in some cases, under the action of a damaging factor on a denervated tissue or organ, alteration is aggravated and prolonged over time, and the proliferative phase, especially along the periphery of the focus of inflammation, becomes weakly expressed. Along with this, many cases are described when, under conditions of denervation under local damaging effects, for example, inflammation of the skin caused by a thermal burn, the manifestations of alteration, as well as vascular exudative changes, are less pronounced than under ordinary conditions. However, the aggravation of the inflammatory process still occurs due to weakening tissue repair, most pronounced on the periphery of the focus of inflammation. It is likely that the nerve effects in the inflammatory tissue are of varying importance at the site of the direct action of the damaging agent and the surrounding area, where various reactions of cells, intercellular substance and microvessels to this damage are formed.
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Neuro-trophic effects and alternative processes in inflammation
- Neuro-trophic effects and proliferation in inflammation
Neuro-trophic influences determine the level of tissue maturity and its ability to renew protein composition, biogenesis of ultrastructures, cell proliferation and intercellular substance. These intra- and extracellular processes are controlled by trophogens, and therefore, with changes in the nerve apparatus in the tissue of the focus of inflammation, certain variations in proliferative phenomena developing in
- Neuro-trophic effects and vascular-exudative changes in inflammation
It can be considered proven that changes in neural influences and neurotrophic function in the focus of inflammation affect microcirculation and take part in the formation of vascular exudative processes. However, the specific mechanisms of these influences are not yet clear. The question is being discussed about what causes a change in the properties of microvessels during inflammation - a violation of their nervous regulation. If you accept that in
- Alterative and exudative inflammation
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- Modern concepts of neuro-trophic function
Under the trophic trophic understand the trophic influences of a neuron, which provide normal life activity of the structures innervated by it - other neurons and tissues. Neurotrophic influence - is a special case of trophic interactions between cells and tissues, cells of the same population (neuron - neuron) and different populations (neuron - executive cell). The meaning of cell interaction
- Inflammation. Definition, essence, mediators of inflammation. Local and general manifestations of exudative inflammation, morphological manifestations of exudative inflammation. The answer is the acute phase. Ulcerative necrotic reactions with inflammation.
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- Changes in the central nervous system during aging, degenerative processes and dementia (dementia)
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- The effect of the focus of inflammation on the body
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- Recommended products for exacerbation of liver inflammation and acute gallbladder inflammation
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- The role of the nervous and endocrine systems in the pathogenesis of inflammation
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- The effect of the parasympathetic nervous system
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- The influence of various factors on the development of the epidemic process
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