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Cancer and inflammatory bowel disease

Patients with chronic inflammatory diseases of the colon are at increased risk of developing cancer. But the degree of risk has not yet been determined. A study conducted by British scientists covered 624 patients with inflammatory bowel diseases and found that only 3.5% of patients developed colon and rectal cancer, although the predicted number was 7 times greater. Intestinal cancer was diagnosed on average to patients aged 41 years (fluctuations ranged from 20 to 74 years). Colorectal cancer occurred in 22% of cases (38% was predicted). Probably, of the many factors influencing the appearance of inflammatory bowel disease, the most significant is the age of the patient.

It is believed that the duration of ulcerative colitis is a determining factor in the possibility of developing colon adenocarcinoma. Cancer often develops in patients with pancolitis (13%) than in patients with inflammation of the left transverse colon (5%). In the latter, cancer develops on average 10 years later. In the first 10 years of inflammatory bowel disease, the incidence of colorectal cancer is 1% and subsequently progressively increases to 7% after 20 years of the course of the disease, to 16% after 30 years and reaches 53% after 40 years.

Patients with Crohn's disease have an increased risk of developing colorectal cancer, but in this case, cancer is less common than with ulcerative colitis. It is very difficult to reliably estimate the incidence of cancer in these diseases, but it has been shown that with them, the incidence of carcinomas of the colon, stomach and small intestine, as well as lymphomas, significantly increases.

The survival rate of patients with colon cancer on the background of ulcerative colitis and without it is the same. To improve the prognosis in patients with colon cancer on the background of colitis, numerous attempts are made to early identify the neoplastic process.
Dysplasia is one of the first signs of a possible cancer development. A standard classification of various dysplasias has now been developed. This is very important, because often the picture of inflammation with subsequent tissue regeneration is similar to the early stages of the development of the neoplastic process. True dysplasia is a benign neoplastic formation morphologically similar to adenomatous tissue. As with the occurrence of a small adenoma, the clinical course of low-grade dysplasia is difficult to predict. The biopsy detection of the existence of such dysplasia can have three explanations. First, it reflects the presence of inflammation, followed by tissue repair (transient stage). Secondly, this dysplasia may indicate the presence of a highly differentiated formation (carcinoma) near the biopsy site. Third, this may be a reflection of a common neoplastic process that occurs in the intestine. In this case, the presence of a tumor somewhere in the intestine cannot be ruled out. Dysplasia is an elevation or plaque, and when it is detected, it is necessary to seriously consider the question of resection of the intestine. If, with numerous biopsies of the mucous membrane, low-grade dysplastic changes are detected, they are unlikely to be caused by a cancer located somewhere nearby. But still, this is cause for concern. The tactics of managing a patient with undifferentiated dysplasia against ulcerative colitis is the same as the tactics of managing patients with an adenomatous polyp without signs of colitis. If highly differentiated dysplasia is detected in combination with a palpable formation in the intestine, it is necessary to perform a total colonectomy. An intraoperative study of this formation usually reveals the presence of highly differentiated dysplasia (carcinoma in situ) or invasive cancer.
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Cancer and inflammatory bowel disease

  1. Idiopathic inflammatory bowel disease
    The group of inflammatory bowel lesions of unknown origin currently includes two diseases: Crohn's disease and ulcerative colitis. These diseases have a lot in common, so they were combined into one group. Both of them are chronic, recurrent, inflammatory diseases of unknown origin. Crohn's disease is a granulomatous disease that can
  2. Idiopathic inflammatory bowel disease.
    Idiopathic chronic inflammatory bowel disease - Crohn's disease and ulcerative colitis. The latter in Russian-language literature is designated as ulcerative colitis. Crohn's disease is an inflammatory disease involving all layers of the intestinal wall in the process and is characterized by an intermittent (segmental) nature of the lesion of various parts of the gastrointestinal
  3. Chronic diffuse inflammatory diseases of the lungs. Bronchial asthma. Lungs' cancer. Pneumoconiosis
    1. The main types of diffuse lung lesions 1. interstitial 4. small focal 2. obstructive 5. panacinar 3. restrictive 2. Causes of death with obstructive emphysema 1. gas acidosis and coma 2. renal failure 3. left ventricular heart failure 4. right ventricular heart failure 5. collapse of the lungs with spontaneous pneumothorax 3. The most important
  4. Bowel disease. Infectious enterocolitis (dysentery, typhoid fever, cholera). Nonspecific ulcerative colitis. Crohn's disease. Coronary bowel disease. Appendicitis. Colon cancer
    1. Macroscopic characteristics of the small intestine with cholera enteritis 1. a gray-yellow film tightly adhered to the wall 2. ulceration of the mucous membrane 3. multiple hemorrhages 4. wall sclerosis 2. Elements of the pathogenesis of typhoid fever 1. bacteremia 2. bacteriocholia 3. cerebral swelling 4. exudative inflammation 5. hypersensitivity reaction in the lymphoid apparatus 3. Modern
  5. III. INTESTINAL CANCER
    Colon cancer currently occupies 3rd place among its other locations and, according to various authors, makes up 98-99% of all intestinal cancers. Colon cancer is twice as likely to affect men than women. The most common tumor location is the sigmoid (25-30%) and, especially, the rectum (about 40%). All other parts of the colon are significantly affected by the cancer.
  6. LUNG DISEASES. CHRONIC DIFFUSIVE ASTHMA. INTERSTITIAL LUNG DISEASES. CANCER INFLAMMATORY LUNG DISEASES. Bronchial lung
    LUNG DISEASES. CHRONIC DIFFUSIVE ASTHMA. INTERSTITIAL LUNG DISEASES. CANCER INFLAMMATORY LUNG DISEASES. BRONCHIAL
  7. Inflammatory bowel disease (ulcerative colitis, Crohn's disease)
    Inflammatory bowel disease (ulcerative colitis, disease
  8. . INTESTINAL DISEASES
    Intestinal diseases can be non-inflammatory and are expressed in diarrhea and constipation (constipation) and inflammatory - enterocolitis and parasitosis. The reason for the cat intestinal dysfunction may be feeding errors (mainly overeating, excess carbohydrates, fats), primary increase in peristalsis (especially in very mobile animals). This phenomenon is not pathological and does not require
  9. 3. The consequences of inflammatory diseases.
    Long-existing infectious diseases are often the cause of emotional instability in women. They also bring disharmony into sex life. In the end, all inflammatory diseases of the female genital organs lead to serious reproductive health problems. The consequences of untreated inflammatory diseases are very diverse and extensive. But, in any
  10. Bowel disease
    INTESTINAL DISEASES are quite common, but the true incidence is not exactly known, since the defeat of the intestine can be either an independent pathology or accompany other digestive tract diseases (for example, xR ° ptosis ™ ™ ™ No.> chronic pancreatitis). Accurate monitoring of the incidence of the disease ™ ecch ™ is also difficult because the intestines have various pathological effects
  11. Bowel disease
    There are a large number of structural features of the intestines of horses, which predispose to the development of diseases. These include: • The inability to vomit means that the horses are prone to gas buildup in the stomach (and as a result to pain) after eating carbohydrate-rich foods. With a large increase in pressure inside the stomach, which can occur if there is physical blockage of the thin
  12. Inflammatory diseases
    The inflammatory genesis of miscarriage is due to the peculiarities of the penetration of microorganisms through the placenta to the fetus from maternal blood. The presence of microorganisms in the mother may be asymptomatic or accompanied by characteristic signs of an inflammatory disease. Often, the pathogen, passing through the placenta, causes the development of placentitis with certain histopathological
  13. Allergic bowel disease
    DEFINITION Early IW with the introduction of foreign proteins (cow, soy) can lead to the development of food allergies in a newborn, especially at risk for allergic diseases. Allergic diseases of the gastrointestinal tract include allergic enterocolitis, enteropathy and eosinophilic esophagogastroenteritis. The role of allergy in the genesis of some other diseases is assumed. CODE ON ICD-K52.9
  14. Vascular bowel disease
    The systems of the superior and inferior mesenteric arteries, as the intestines reach, are characterized by progressive branches. Rich inter-arterial connections are formed through the arch mesenteric trunks. Numerous collateral vessels connect these systems in the proximal direction with the celiac trunk system, and in the distal one with the circulatory network of the external genital organs. Similar
  15. INFLAMMATORY DISEASES OF THE NANOLAIN SINAS
    Inflammatory diseases of the paranasal sinuses (sinusitis) are among the most common diseases of the upper respiratory tract. According to the literature, patients with sinusitis make up about 1/3 of the total number of hospitals hospitalized in ENT (Kozlov M.Ya., 1985; Soldatov IB, 1990; Piskunov GZ et al., 1992; Aref'eva N.A. , 1994). The foci of inflammation in the paranasal sinuses can be a source
  16. Female genital inflammatory diseases
    Inflammatory diseases of the female genital organs (VZPO) occupy the first place in the structure of gynecological diseases. About 40% of gynecological patients in the hospital have VZPO. The cause of all inflammatory diseases of the genitals are microbes, which most often enter the body of a woman through sexual contact. Pathogens can also spread by the lymphogenous, hematogenous route,
  17. Infectious and inflammatory diseases of the urinary system
    The group of infectious and inflammatory diseases of the urinary system is the most frequent and studied among the nephropathies that occur in newborns and young children. The share of infectious and inflammatory diseases of the urinary system accounts for most of the nosological forms of nephropathy in childhood. Difficulties in determining the localization of the pathological process, especially in newborns
  18. Inflammatory diseases of the nasal cavity
    Consideration of inflammatory diseases of the nasal cavity must be preceded by a summary of a number of fundamental principles contained in the capital work of V.I. Voyacheka "Fundamentals of Otorhinolaryngology" (1953), many of which have not lost their significance at present. Inflammatory diseases of the nose V.I. Voyachek suggests considering as a reactive response of the mucous membrane and
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