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Mobilization (expenditure) of fat.
When this occurs, the release of fatty acids from the reserves of adipose tissue. They enter the bloodstream, bind to plasma albumin and become available for use by other tissues.
The destruction of fats inside adipocytes is catalyzed by lipase. This enzyme is always present in fat cells and is known for its hormonal dependence. It is inactive at a high level of the same insulin.
That is, insulin, affecting the activity of this enzyme, inhibits the release of fat.
But besides this, the already released fatty acids are bound by the action of insulin, their re-esterification is stimulated. This effect, which is very sensitive, develops at relatively low insulin concentrations, and very fast occurs in just minutes of an increase in insulin concentration.
That is, insulin, not only activates the fat supply, but also blocks its mobilization (disintegration).
Normally, the capture of fatty acids after a meal is balanced by the process of mobilizing fat in the post-absorption stage (for example, during an overnight fast) or during exercise, while for many people the amount of stored fat remains constant over a long period of time. However, as we have just found out, a state may develop in which, due to the increased content of insulin in the blood (hyperinsulinemia), fat deposition predominates over its mobilization, and vice versa.
In order to help you understand all this biochemistry, I will give two simple illustrative examples, described by Michel Montignac.
For example, you eat a simple piece of bread. What's happening?
Bread is a carbohydrate, its starch is quickly transformed into glucose, which enters the blood. The body immediately enters the stage of hyperglycemia, that is, in a state of sharp increase in blood glucose. The pancreas responds immediately to this by insulin release, which, by lowering blood sugar levels, causes glucose to flow to the organs in need, thereby creating energy for the vital needs of the body. There is no fat here, and there is simply nothing to postpone. Although the process of fat breakdown is inhibited.
In another case, when you eat a piece of bread and butter, the bread is carbohydrate, it will be processed into glucose, and the oil, lipid, into fatty acid. Both that and another gets to blood. The level of sugar in the blood immediately increases, the pancreas secretes insulin.
At the same time, if your pancreas is in excellent condition, it will release exactly as much insulin as is needed to process the glucose that has entered the blood. If it is “sick,” and insulin sensitivity is reduced, then its amount will far exceed the dose needed to process glucose and it will immediately drag the fats under the skin. As a result, part of the lipid (from the oil) is deposited in reserve - in the fat. It's simple!
Therefore, it is clear that weight gain depends on the state of your pancreas and the body's insulin sensitivity. A person with a healthy gland can eat absolutely everything and in any quantity, while remaining at a normal weight and not fat. A person prone to obesity has a tendency to hyperinsulism and, as a result, to obesity.
The fixation of fat in fat cells is carried out by the same hormone - insulin, which is produced by pancreatic cells. As the level of fat in the blood of the pancreas rises, more and more efforts are needed to keep the fat in the fat cells. The insulin level in the blood begins to rise, and sensitivity to it is lost.
Of course, the mechanism for the development of obesity is much more complicated and each can follow a specific “scenario”, but it is always based on the interaction of insulin fats and carbohydrates.
It may be difficult to understand what I am writing about, and maybe you already knew about it or at least heard it. But believe me, as my medical experience shows, most of my patients had no idea about this before they met me.
Well then. Due to what is the deposition of excess fat, and what underlies this pathology, we seem to have understood. Now the question is, what to do with it? Does this pathological violation of insulin sensitivity permanently deprive us of the chance to get rid of excess fat?
Not! Nothing is impossible! The main thing is your desire, faith in victory and the help of a competent specialist. We will talk about the importance of motivation and confidence in the results. This topic is worth considering separately. About when you really need the help of a doctor, and when you can try to solve everything yourself, I’ll also tell you.
In the meantime, let us try to outline and substantiate the first of the general principles of treatment laid down in the basis of the method created by me.
As we all usually do, when we have an arm, leg, or other part of the body damaged. Most often, we bandage and provide maximum rest to the injured organ. Probably, it is clear that we cannot put a bandage on the pancreas, but now we can create the conditions for the necessary rest, remove the extra load from it.
And, of course, this contributes to the restriction or, if you wish, the removal from the diet of foods with a high glycemic or insulinemic index. Under the ban sent all meals containing sugar, flour products, potatoes and white rice. Foods high in carbohydrates should be excluded from the diet. All this is either refined products (flour, sugar, white rice), or industrially processed (corn flakes, popcorn and rice, sweets, glazed with chocolate, beer), or so-called new products, that is, those that are consumed in Russia. for no more than 200 years (potatoes, corn).
What, then, is, you ask, seeing sweets, flour and potatoes in this list?
There is a way out - you have to remember the traditions and return to the dishes of the national Russian cuisine, especially the fasting table (vegetable, fish and mushroom). There you will find a lot of delicious and healthy dishes, which with success you will replace and fried potatoes, and white bread, and tea with sugar.
Scientists from Harvard University as a result of a large-scale study, which lasted for 20 years with the participation of 84,555 American women, found that frequent use of potatoes increases the risk of diabetes mellitus type II in women.
For these women, who often consumed potatoes, the risk of developing insulin-dependent diabetes mellitus for 20 years increased by 14% compared with those who ate potatoes extremely rarely. And for lovers of french fries, the risk level was 21%. Potatoes are rich in minerals, mainly potassium, and are especially useful for people with heart and kidney disease. However, the consumption of this vegetable leads to a sharp increase in blood glucose levels. With predisposition, this may contribute to the development of type II diabetes and obesity.
Vegetables can be recommended to exclude beets and carrots from the diet, and bananas and grapes from fruits.
Over time, with proper nutrition, insulin sensitivity can recover, and the pancreas will no longer need to release insulin in such an amount, and fat deposits will not occur. I think the mechanism here is clear. In addition, as you remember, the sugars that enter the blood immediately from food are consumed first. Then carbohydrates accumulated as glycogen in the liver and muscles. Then the eaten fat and proteins are consumed, and only in the fourth place - the fat from the fat reserves.
Thus, by creating permanent restrictions on carbohydrates and fats, preventing the body from replenishing its reserves of adipose tissue, we will force it to use its own adipose ballast.
If even a minimal surplus of carbohydrates and fats appears in the food, then the fats will certainly be deposited in the form of a reserve reserve, and the person will begin to get fat. Well, if we limit carbohydrates in the diet and reduce the amount of fat, the body's metabolism will begin to work according to the basic model, that is, to use the reserves of fat on the demand of the body's energy.
This is normal. But there are always exceptions.
As I wrote, in no case can not completely exclude carbohydrates from the daily diet, you should only replace the use of foods containing sugar and having a high glycemic index, for example, the same fruit or brown rice. Without creating a shortage of carbohydrates in the body, we simultaneously control the release of insulin into the blood! This is a very important rule!
But there are people who just can not live without sweet. This has a rather figurative name - “carbohydrate thirst”. They can not be forced to completely abandon the sweet and flour. They always need large amounts of carbohydrates. This is not a whim, as thought before! This is the need of their body!
In general, it is worth remembering one simple truth. Our body is a complex self-regulating system with a huge life potential. And if he wants something, it means that he lacks this.
So what happens? Why do sweet teeth need sugar?
To answer this question, let's understand how the absorption of sugar (glucose) in the body.
There are two ways to break down glucose: glycolysis and the pentose phosphate pathway.
For ease of understanding, I can only say that if glycolysis plays an important role in energy metabolism, then the pentose phosphate pathway eventually leads to the formation of fats. And, as it turned out, this is due to a deficiency in the body of a number of trace elements and, above all, chromium.
The lack of this particular element often causes a shift in the carbohydrate metabolism process to the pentose phosphate cycle. At the same time, a person is forced to consume more sweets, and the nervous system still receives less sugars, since most of them are processed and deposited in fats. But it is worth to add such preparations of chromium to the ration of sweet teeth, as they literally before our eyes forget about the “sweet life”.
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Mobilization (expenditure) of fat.
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