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Disarming Toxins - Liver Function
Toxins and mucus that are released into the circulatory and lymphatic systems, as soon as the detoxification mode is activated, should be neutralized and removed from the body. Why? Because they contain free radicals - electrically charged molecules, which, upon contact, corrode tissue and damage cells. In addition, they disrupt various functions - cell division and reproduction, hormone production and release - and receptor sensitivity. As mentioned above, they even affect the expression of genes. Since toxins, especially man-made, like fats, lingering without neutralization for a sufficiently long time in the circulatory and lymphatic systems, they find fatty tissues and invade them. Their main goal is the brain, much of which are fat.
It is not surprising that neurological disorders result from the accumulation of toxins.
Since fat is difficult to get rid of (as everyone knows), the released toxins must be converted from molecules soluble in fats into molecules soluble in water that are easier to remove from the body. The main role is played by the liver. The chemical detox reactions that take place in the liver are carried out in two phases. In the 1st phase, the structure of the toxin to be neutralized is changed, and it is converted into an intermediate metabolite. In some cases, this intermediate product is more toxic than the toxin from which it originated. The intermediate metabolite needs to be transferred as quickly as possible to the 2nd phase of hepatic detoxification, where its toxic properties are neutralized and it turns into a water-soluble product that can be sent back to the circulatory system and through its vessels further to the kidneys.
The kidney cells recognize it, take it out of the bloodstream and out into the urethra along with urine.
To detoxify, the liver needs energy and a constant supply of antioxidants (to neutralize free radicals) and other minerals, vitamins and nutrients. If all this is available, detoxification is successful.
The transition between phases occurs so quickly that the intermediate compounds do not have time to break free. However, if the liver does not receive such support, the implementation of the 2nd phase is under threat. Partially converted toxins return from the liver back to the circulatory and lymphatic systems and through them further to the tissues and cells, which damage by reintroducing into them. Other detoxification organs may try to make up for this failure, but none of them have such capabilities as the liver. Various systems are subjected to a series of stresses, as a result of which the body experiences even greater stress. Knowing this, you will understand why starvation in itself, although it accelerates the elimination of toxins from tissues, can be detrimental to health. It blocks access to the body of nutrients that contribute to the implementation stage of processing and neutralization, which must then occur.
You will see the beneficial effect of detoxification in the third week: the skin will gain shine, the whites of the eyes will become whiter, the clothes will sit on you more freely, and your friends will be interested in whether you were on vacation and not done a face lift
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Disarming Toxins - Liver Function
- Liver function Synthetic function
In the liver, they synthesize: - many high-molecular proteins, which have the main role in maintaining oncotic blood pressure, and they are the main carriers of bilirubin, certain hormones and a number of drugs. Therefore, liver diseases leading to hypoalbuminemia can cause peripheral edema, ascites, hydropericardium and hydrothorax (anasarca),
- Laboratory evaluation of liver function
Unfortunately, the sensitivity and specificity of most of the applied laboratory tests of liver function is not very high. For example, the serum aminotransferase concentration more reflects the integrity of hepatocytes than liver function. Only two standard tests allow to evaluate the synthetic function of the liver: serum albumin concentration and prothrombin time (PT). With cirrhosis
- Digestive system. Liver function
During pregnancy, hypotonia of the gastrointestinal tract is noted, both as a result of the corresponding neurohormonal changes and as a result of topographic exposure from the increasing uterus size. The enlarged uterus causes displacement of the stomach and intestines. The stomach, in contrast to its natural horizontal position, acquires a vertical position, moves upward and
- Liver structure and function
In order to properly understand hepatobiliary pathology, it is necessary to have knowledge of the anatomy and ultrastructure of the biliary tract of the liver (Fig. 7-1). Hepatocytes are located in one row, forming a dense cell plate. Hepatocytes are separated from the bile capillaries by the basolateral membrane, and from sinusoids by the sinusoidal membrane. Due to the difference in the structure of the sinusoidal membrane and the membrane facing the biliary
- Vascular liver function
Regulation of hepatic blood flow Normally, hepatic blood flow in adults is about 1500 ml / min; 25-30% of it is provided by the hepatic artery and 70-75% by the portal vein (Fig. 34-2). The liver's need for oxygen satisfies the hepatic artery by 45–50%, the portal vein for the remaining 50–55%. Pressure in the hepatic artery is equal to systemic blood pressure, while the pressure in the portal vein is <10
- DISTURBANCE OF FUNCTIONS OF THE LIVER AND JOURNAL DUCTS
The liver plays a leading role in the metabolism of proteins, fats, carbohydrates, hormones, vitamins, minerals, as well as many exogenous compounds. In the liver, albumin, fibrinogen, prothrombin, and some other blood doorway factors are synthesized, heparin, a- (3- and (partially) uglobulin, a number of enzymes are produced. In the liver, glycogen is synthesized, deposited and decomposed
- Liver dysfunction in the postoperative period
Liver dysfunction is not uncommon in the early postoperative period and can occur in the form of transient fermentation and liver failure of varying severity. The actions of the surgeons can cause compression of the biliary tract or hepatic ligament, leading to liver ischemia. Most often this is a consequence of the long standing of the turnstile on the hepato-duodenal
- The effect of anesthesia on liver function
Hepatic blood flow During regional and general anesthesia, the hepatic blood flow decreases. This effect is mediated by various factors, including the action of anesthetics, the nature of the respiratory support and the type of operation. All inhalation anesthetics reduce blood flow in the portal vein. Halothane causes the most significant decrease, and isoflu-wound is the least pronounced. Moreover, isoflurane is
- Jaundice and abnormal liver function
Jaundice and impaired function
- Diseases of the liver and biliary system. Hepatitis. Cirrhosis of the liver. Liver cancer. Cholelithiasis.
1. A woman of 40 years old complains of weakness, jaundice. In history for 2 months. before the disease - blood transfusion. The examination revealed an increase in the liver, an increase in the level of liver transaminases. Conclusion 1. hepatic steatosis 3. obstructive jaundice 2. Botkin's disease 4. acute viral hepatitis 2. Viral hepatitis C is characterized by 1. high frequency of chronicity 2. parenteral transmission 3.
- Liver weakness, blockage in it and everything related to liver pain
Liver weakness Says Galen: "The liver is a person whose actions in the liver show weakness in the absence of an external cause — a tumor or an abscess." In fact, liver weakness accompanies liver disease and [occurs] either from a disorder of simple nature without matter, or from [disorder] with matter. The source of the [disorder] is either the liver itself or others.
- Liver cirrhosis ("shrinking" of the liver)
Causes Inflammation or poisoning of the liver, resulting in healthy cells regenerate into scar tissue. With the development of pathology, the liver decreases in volume, the number of healthy cells decreases, the portal vein transporting blood from the gastrointestinal tract narrows. As a result, blood pressure rises in the liver, fluid accumulates in the abdomen and possibly varicose veins in the esophagus.
T-2-toxin is a product of the vital activity of the fungi of the genus Fusar-ium, therefore, until the end of the 60s, toxicosis caused by this mycotoxin was diagnosed as fusaryotoxicosis. Many authors studied the study of fusariotoxicosis in our country (A. Kh. Sarkisov, 1948; M. I. Salikov, 1956; NA Spe-sivtseva, 1966; I. A. Kurmanov, 1960–1971, and others). Clinic of fusariotoxicosis in large
- What is toxin?
Toxin is something that disrupts the normal course of physiological processes and has a negative effect on body functions. Toxins are divided into many different types, with completely different properties, originating from many different sources and having different destructive mechanisms. Regardless of how you feel about this issue, knowing what is
- BACTERIAL TOXINS
Classification of bacterial toxins. Louis Pasteur in 1887, experiments were conducted proving that the substances that are formed as a result of the activity of microorganisms and are in the nutrient broth, can cause the same clinical signs of the disease, as when infected with the pathogen. E. Ru and A. Yersin in their experiments in 1889 confirmed this conclusion.