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lupus erythematosus

Lupus erythematosus is a group of connective tissue diseases that have autoimmune pathogenesis and affect predominantly exposed skin and internal organs.

Etiology and pathogenesis. Hereditary predisposition and, apparently, viral infection, which contribute to the development of autoimmune processes, have a leading role in the etiology of lupus erythematosus.

Clinic. Mainly predominantly cutaneous and intravenous forms of lupus erythematosus. Among the skin forms emit discoid, disseminated and deep forms of the disease. Discoid lupus erythematosus affects mainly the skin of the face: the nose, cheeks, auricles, and the adjacent skin, forehead, chin, lips, scalp. Often affects the red rim of the lips. Characterized by a long relapsing course with exacerbations mainly in spring and summer. Symptoms of systemic lesions are extremely rare.

For the disseminated form, the defining characteristic is the formation of small, slightly infiltrated erythematous plaques with a slight tendency to peripheral growth, covered with tightly seated scales. Scraping reveals tenderness. Typical localization is the skin of the face, scalp, ears, upper chest and back, and the back of the hands. After the resolution of foci, mild atrophy usually remains.

There is a special form - the so-called subacute cutaneous form of lupus erythematosus. This form is characterized by common ring-shaped lesions on the skin, which, when merged, form polycyclic flaking areas along the edges of the chest, back and limbs with hypopigmentation and telangiectasias in the central part.

The deep form of lupus erythematosus (lyuspunniculitis) is manifested by the formation of one or two asymmetrically located subcutaneous nodes.
The nodes are dense, mobile, flat, little protrude above the surrounding skin and better detected by palpation.

Systemic lupus erythematosus can develop acutely, often without cutaneous manifestations or subacutely and chronically, when there is a skin lesion.

In systemic lupus erythematosus, the most common manifestations are: fever, skin rashes, arthralgia, arthritis, serous membranes, lymphadenopathy, carditis, Raynaud's syndrome, characterized by the detection of autoantibodies to DNA.

A typical skin lesion is a swollen erythema on the face, resembling a butterfly, gradually spreading to the neck and chest.

Diagnostics. The basis for the diagnosis of cutaneous lupus erythematosus is the identification of the main clinical symptoms of skin lesions. Important laboratory results. Characterized by a significant increase in ESR, hypochromic anemia, leukopenia, thrombocytopenia, dysproteinemia, the presence of LE cells, the identification of antinuclear factor and anti-nuclear autoantibodies.

Treatment. In all forms of lupus erythematosus, protection against insolation and cold should be used. In skin forms of the disease, aminoquinoline preparations are used. Topical steroids can more quickly achieve clinical effect and reduce the severity of cicatricial atrophy in discoid form of lupus erythematosus. In systemic lupus erythematosus, systemic glucocorticosteroids serve as the main therapeutic agent.
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lupus erythematosus

  1. lupus erythematosus
    Lupus erythematosus - collagenosis, an important role in the pathogenesis of which is a violation of the regulatory function of T-lymphocytes, the appearance of immune complexes and their deposition in the tissues. Mostly women are ill (about 90%) at the age of 20-45 years. The causes of the disease are unknown. It is assumed that provoking factors (some chemicals, drugs, infection) in combination with
  2. Neonatal lupus erythematosus
    DEFINITION Newborns from mothers with systemic lupus erythematosus and other diffuse connective tissue diseases may have transient dermal lupus, heart rhythm disturbances (congenital heart block) and hematological disorders (thrombocytopenia, leukopenia, hemolytic anemia), as well as immunological signs of systemic lupus erythematosus what is called
  3. Systemic lupus erythematosus
    There are acute and chronic forms of lupus erythematosus. The acute form is characterized by pale red and red edematous rashes, often on the face, which merge into spots. Rashes can be found on the body, buttocks, limbs, often on the hands and fingers, less often on the mucous membranes. They resemble seborrheic eczema or exudative erythema. Sometimes foci are combined with bubbles and
  4. SYSTEM RED LADY
    Systemic lupus erythematosus (SLE) is a systemic autoimmune disease of unknown etiology based on a genetically determined disorder of immunoregulatory mechanisms that determines the formation of a wide spectrum of organ-specific autoantibodies to various components of the nucleus and the formation of immune complexes that cause the development of immune inflammation in the tissues of various organs.
  5. Systemic lupus erythematosus
    Systemic lupus erythematosus is a chronic polysyndromic disease of the connective tissue and blood vessels, developing in connection with the genetically determined imperfection of immunoregulatory processes. Etiology. The significance of viral infection against the background of genetically determined immunity disorders is assumed. Pathogenesis: circulating antibodies are formed, of which important diagnostic and
  6. Systemic lupus erythematosus
    Systemic lupus erythematosus (SLE) is an acute or chronically occurring systemic disease with severe autoimmunization characterized by a predominant lesion of the skin, blood vessels, and kidneys. • Mostly young women get sick. • Insolation and taking certain medications are often provoking factors. • The processes of autoimmunization are accompanied by the appearance of antinuclear autoantibodies to
  7. RED LADY (LUPUS ERYTHEMATODES)
    Etiopathogenesis. Dermatosis is etiologic. Theories of the origin of lupus erythematosus: 1. Autoimmune theory - it plays the main role. In the serum of patients with lupus erythematosus detect a high level? - globulins, among which an unusual protein - macroglobulin, the so-called anti-nuclear factor, damaging the nucleus of cells, especially leukocytes. In peripheral blood and
  8. Systemic lupus erythematosus.
    Systemic lupus erythematosus is a disease of the autoimmune nature. With the development of the disease by the patient's body, antibodies are produced to the nuclear substances of their own cells. Mostly sick girls - teenagers. Fever can be constant for weeks and months. Its reason is long incomprehensible. Rash. "Lupus butterfly" - a group of small and medium in size
  9. SYSTEM RED LADY
    Systemic lupus erythematosus (SLE): a nonspecific autoimmune disease of the body, which is accompanied by lesions caused by cytotoxic antibodies and the deposition of immune complexes. SLE is observed in many species of mammals (man, mouse, monkey, cat, dog and horse). As a rule, the disease occurs in a subacute or - more often - in a chronic form, accompanied by
  10. Systemic lupus erythematosus
    Systemic lupus erythematosus (SLE) is a chronic polysyndromic disease, predominantly in females, developing against the background of genetically determined imperfections of immunoregulatory processes, leading to uncontrolled production of antibodies to its own cells and their components with the development of autoimmune and immunocomplex inflammation. EPIDEMIOLOGY. Accurate data about
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