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lupus erythematosus

Lupus erythematosus is a group of connective tissue diseases that have autoimmune pathogenesis and affect mainly exposed areas of the skin and internal organs.

Etiology and pathogenesis. The leading importance in the etiology of lupus erythematosus is a hereditary predisposition and, apparently, a viral infection, which contribute to the development of autoimmune processes.

Clinic. Mainly skin and dark forms of lupus erythematosus are distinguished. Among skin forms, discoid, disseminated and deep forms of the disease are distinguished. Discoid lupus erythematosus affects mainly the skin of the face: nose, cheeks, auricles and adjacent skin, forehead, chin, lips, scalp. The red border of the lips is often affected. A characteristic long recurrent course with exacerbations mainly in spring and summer. Signs of systemic damage are detected extremely rarely.

For the disseminated form, the determining feature is the formation of small, weakly infiltrated erythematous plaques with a slight tendency to peripheral growth, covered with tight-fitting scales. When scraping, soreness is detected. Typical localization is the skin of the face, scalp, auricles, upper chest and back, rear of the hands. After resolving the foci, mild atrophy usually remains.

Allocate a special form - the so-called subacute skin form of lupus erythematosus. This form is characterized by common ring-shaped lesions on the skin, which, when fused, form polycyclic flaky areas on the edges of the chest, back and limbs with hypopigmentation and telangiectasias in the central part.

The deep form of lupus erythematosus (lupuspanniculitis) is manifested by the formation of one or two asymmetrically located subcutaneous nodes.
The nodes are dense, mobile, flat, protrude slightly above the surrounding skin and are better detected by palpation.

Systemic lupus erythematosus can develop acutely, often without skin manifestations or subacute and chronically when there is a skin lesion.

In systemic lupus erythematosus, the following manifestations are most common: fever, skin rashes, arthralgia, arthritis, damage to the serous membranes, lymphadenopathy, carditis, Raynaud's syndrome, detection of autoantibodies to DNA is characteristic.

A typical skin lesion is swollen erythema on the face, resembling a butterfly, gradually spreading to the neck and chest.

Diagnostics. The basis for the diagnosis of skin forms of lupus erythematosus is the identification of the main clinical symptoms of skin lesions. The results of laboratory studies are important. Significant increase in ESR, hypochromic anemia, leukopenia, thrombocytopenia, dysproteinemia, the presence of LE cells, the detection of antinuclear factor and antinuclear autoantibodies are characteristic.

Treatment. For all forms of lupus erythematosus, means of protection from insolation and cold should be used. With skin forms of the disease, aminoquinoline preparations are used. Topical steroids allow you to more quickly achieve a clinical effect and reduce the severity of cicatricial atrophy in the discoid form of lupus erythematosus. With systemic lupus erythematosus, the main therapeutic agent are systemic glucocorticosteroids.
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lupus erythematosus

  1. lupus erythematosus
    Lupus erythematosus is collagenosis, an important role in the pathogenesis of which is played by a violation of the regulatory function of T-lymphocytes, the appearance of immune complexes and their deposition in tissues. Mostly women (about 90%) aged 20–45 years are ill. The causes of the disease are unknown. Provoking factors (certain chemicals, drugs, infection) are thought to be combined with
  2. Neonatal lupus erythematosus
    DEFINITION Newborns from mothers with systemic lupus erythematosus and other diffuse connective tissue diseases can have transient skin lupus erythematosus lesions, cardiac arrhythmias (congenital heart block) and hematologic disorders (thrombocytopenia, leukopenia, hemolytic anemia), as well as immunological signs of systemic lupus erythematosus which is called
  3. Systemic lupus erythematosus
    There are acute and chronic forms of lupus erythematosus. The acute form is characterized by pale red and red swollen rashes, often on the face, which merge into spots. Rashes can be found on the trunk, buttocks, limbs, more often on the hands and fingers, less often on the mucous membranes. They resemble seborrheic eczema or exudative erythema. Sometimes the foci are combined with bubbles and
  4. Systemic lupus erythematosus
    Systemic lupus erythematosus (SLE) is a systemic autoimmune disease of unknown etiology, which is based on a genetically determined violation of immunoregulatory mechanisms, which determines the formation of a wide range of organ-specific autoantibodies to various components of the nucleus and the formation of immune complexes that cause the development of immune inflammation in the tissues of various organs.
  5. Systemic lupus erythematosus
    Systemic lupus erythematosus is a chronic polysyndromic disease of connective tissue and blood vessels, develops in connection with a genetically caused imperfection of immunoregulatory processes. Etiology. The significance of a viral infection against the background of genetically determined immune disorders is assumed. Pathogenesis: circulating antibodies are formed, of which an important diagnostic and
  6. Systemic lupus erythematosus
    Systemic lupus erythematosus (SLE) is an acute or chronically occurring systemic disease with severe autoimmunization, characterized by a predominant lesion of the skin, blood vessels and kidneys. • Mostly young women are ill. • Provoking factors are often insolation and taking certain medications. • Autoimmunization processes are accompanied by the appearance of antinuclear autoantibodies to
    Etiopathogenesis. Dermatosis is polyetiologic. Theories of the origin of lupus erythematosus: 1. Autoimmune theory - it plays the main role. In the blood serum of patients with lupus erythematosus detect a high level? - globulins, among which an unusual protein was revealed - macroglobulin, the so-called antinuclear factor that damages the nuclei of cells, especially leukocytes. In peripheral blood and
  8. Systemic lupus erythematosus.
    Systemic lupus erythematosus is a disease of an autoimmune nature. With the development of the disease, the patient’s body produces antibodies to the nuclear substances of its own cells. Mostly sick teenage girls. The fever can be constant for many weeks and months. The reason for it is long incomprehensible. Rash. "Lupus butterfly" - a group of small and medium-sized
  9. Systemic lupus erythematosus
    Systemic lupus erythematosus (SLE): A non-specific autoimmune disease of the body that is accompanied by lesions caused by cytotoxic antibodies and the deposition of immune complexes. SLE is observed in many species of mammals (human, mouse, monkey, cat, dog and horse). As a rule, the disease proceeds in a subacute or - more often - in a chronic form, accompanied by
  10. Systemic lupus erythematosus
    Systemic lupus erythematosus (SLE) is a chronic polysyndromic disease, mainly in females, which develops against the background of genetically caused imperfection of immunoregulatory processes, which leads to uncontrolled production of antibodies to own cells and their components with the development of autoimmune and immunocomplex inflammation. EPIDEMIOLOGY. Accurate data on
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