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Інфекційна катарана Гарычка's sheep
Infectious catarrhal garyachka sheep (Febris catarrhalis infectiosa ovium, bluetong, blue tongue) is a viral transmissive spruce, which is characterized by wild grass, necrotic inflamed mucous membranes, and also In zvyazku with the characteristic izmerennyas of the tongue of twig distal I will call “blue tongue” or “black mouth”.
Istorichna dovidka. Blossom on top of Bulo was registered in 1876. at Pivdenny Africі. On the eve of an infectious catarrhal garyachka shepherded a sheep of a great age, I often passed asymptomatically. However, the sheep brought in Africa the sheep of European times (1852 - 1870 r.), The twig scorched an evil character and shvidko spread across the whole continent. Ninі іnfektsіyna catarrhal garyachka to become serioznu iz_izootologіchny і economically problem in usuvomu svіti.
First, I twisted the twig and described Hutchin (1881), and established the nature of Teiler (1906). Sprewell (1901), having expelled the method of immunization of sheep with virulent blood and that of immune syrovatka, and Teyler (1907), after having wiggled atenuovanu, I live the vaccine. In 1947 p. Alexander izoluvav virus at smoking embries.
For the remaining 60 years of catarrhal, the hot cattle sheep fought even better in the African countries, as well as in Palestine, Syria, Iran and Turechchin. In 1948 p. twig Bulo was registered in America, in 1956 - on the portugal of Portugal in Spain, in 1959 - at the Scheduled Pakistan and Japan, in 1946 p. - in Іndії. For the tributes of the International Epizootic Bureau, an infectious catarrhal garyachka was installed in 40 countries of the world, however, the food was 45 ° Mon. w. not registered. To save money on animals, such as making a spruce tree, they are represented by a high degree of illness (10 - 50%) and a lethality (90 - 100%) of creatures, low productivity of sheep, and vitamins for organizing visits. Infectious catarrhal garyachka sheep was presented to the group A, I want to inform me and introduce MEB and introduce mezhmezhna to trade in meat and, at least, that is thin.
Twig Arbor - RNA genomic virus, which can be found before the homeland of Reoviridae, the genus Orbivirus. Vіrіoni may have a spherical shape, diameter 65 - 80 nm, two icosahedral capsidi, 7 structural bіlkіv. Vidomo 24 serotypes to virusu, so as not to assimilate the sheep of a superb imunitetu. Vіrus avenged in blood, blood and plasma, in blood-forming organs, last hour of burning - in spleen, liver, lymph nodes. In the period of supreme clinical signs, the virus is localized in the mucous membranes of the intestines, epithelial and neoplastic tissues. Virusemia in sheep’s trousers for sale 35 - 49 dibs for viduvuvannya, independent of the appearance of blood virusneutralіzuychih antibodies. Virus is cultivated in smoking embryos of 6–8-day or 11–13-day old, in the organisms of new-born birch larvae are targeted, in the first cultures of klitin nyrok lambs ary embryo bovine, as well as in re-hatched lynnin, 21 klnin Helin.
After 2 - 3 dobs of infection, the CPD is declared: rounded klitin, granularity, assimilation of internal plasmatic (RNA-positive) and internal nuclear (DNA-positive) inclusion, fragmentation of monitored balloon. From laboratory creatures to virus, 1–4-day-old targets are targeted, as well as homies.
Vіrus to finish the old one at the middle one. In carcasses, sheep at a pH not lower than 6.3 ° C and at a temperature of 4 ° C can be varied up to 30 dibs, in the blood, conserved in the food of Edison, and at room temperature there will be a loss of food for 25 days. It is resistant to low temperature and must be stored in frozen until -70 ° C sperm. Heated to 60 ° C ruinu virus after 5 hv, at 37 ° C and pH <6 virusinaktivatsya after 1 chv. Під дією 3% reason for formalin virus guinea after 48 - 72 years, 3% reason for pure sodium and 70 ° ethyl alcohol - after 5 cu.
Epizootology twig. Before the ridge of infectious catarrhal garyachki in natural minds, quick and small is horned by thinness, goats, antelopes, elk, American bilhaw deer, snigov vivtsi. Particularly sensitive are the lambs. At the stationary disadvantaged points of the Sisuni lambs, they pass the passive iMunity and do not ill. Dzherelom zbudnika Інфекції є illness and rebuilding vivtsi, scho to become virusonosіami for sale 3 - 4 ms. Moved to virus vid to bring healthy creatures to healthy living Molecules Culicoides, which are characterized by significant expansions and great numbers, as well as Aedes mosquitoes Melophagus ovinus. Naibіlsh a significant reservoir of virus in nature to respect the great horned thinness, in the body of a certain virus to be protected until the offensive active period of the cycle of developing pathetic comas. Through the middle lanka, through the yak, it is also possible to pass to the viral companion to the intimate vivtsam, to be able to eat wild juvenile creatures and grisuni. The contact hole can not be transmitted.
Інфекційна катарана Гарычка's a sheep, it’s characterized by seasonality, and it’s possible to get paid with a period of board and the most active carrier-carrying coma. Epizootic twigs span in lowlands, behind flowing rivers, along the banks of standing waters.
Creatures become infected at different times of the night, but early-wrants. In dry rocky, the dry season, hot year of the day, when the sheep are exterminated at the primaries, as well as in the Girsky zones, there is no way to catch up. An infectious catarrhal garyachka to pass at a place of great importance and with great numbers of populations (50 - 60%), is characterized by severe excesses and a high mortality rate, with a maximum of 90% of them, and 30%.
The pathogenesis of infusion is not enough. Pislya penetration into organism vіrus reproduced in the blood and zoom trivial protopodnitsyu.
With the development of the clinical picture, the virus is located in the glands, the lymph nodes, the liver, and the localized in the mucous membranes of the intestines, the natural and small tissues. Reproduction of virus in the organs of organs and tissues, zoom in and out of rechovin, increased penetration of sudins, development of glow-degenerative and necrotic manifestations, erosion and virazok. The abortion of the fetus is embryonic wiklik є abortion, the birth of undead-born youngsters. In the case of creatures, the resistance to organism is lower, the second is bacterial infection, which can lead to a significant acceleration of the pathological process and the death of creatures.
Particularly infectious process in case of an infectious catarrhal sheep є trial (sale of a month) persistence in blood, independent of the fact that you have to receive the highest possible title.
Clinical signs and interruptions of twigs. Іnkubatsіyniy perіod trivaє 2 - 6 dib. Perebig twig gostrii and pidgostrii. Appear as an abortive form of twigs. From time to time, you can speed up the rapid temperature of the temperature to 40.6 - 42 ° C, yakatryimatsya on the whole river with a length of 6 –12 dB. Immediately, I’m convinced of the pride, a trick to be sure to go, I’ve captured the vіdstayut vіd of the herd.
After 24 - 36 years, the temperature of the body develops, the catarrhal inflamed mucous membranes of the mouth, tongue, pharynx, and nasal empty. There is a head outfit, a language is shorter in volume, a blue-and-red darling, the name of the twig is “blue tongue”. Protein blueprint of a language may not be but after 1 - 2 add a new labelє. At the same time, we’ll see the image from the mouth of the pineal slug (“vologa muzzle”), see the old, impeccable flanks of the tongue, and also see the nose, the watery appearance, and the mucous membrane. Virazkovy abo-gangrenous stomatitis develops, the passage with blood houses is declared.
At the rear end there is a little redness and swelling of the lead, of the parts to ratify, pain in the onslaught.
In bagatokh tvrín, you have to speed up your culture, "go to the go", go to school to learn more, go to the wool. Creatures lose weight i on the 7th - 8th dobu twigs to drive. Lethality can reach 70 - 90%. Viduzhuvannya is now better, not earlier than in 10 - 15 days to lower the temperature. In lambs, pneumonia develops, accelerated by necrobacteriosis, and even 100% of deaths result in death.
Pid hour p і d g about with t about r about to wait for a little more so that they themselves are so klіnіchnі oznaki, as if at gostroma, however the severity of their turn is much less. Triviality of twigs - 12 - 25 db, lethality to become 20 - 60%. And the abortion form of the twig appears less than a short-hour garyachkoy, mlyavistyu, superficial catarrhal inflamed mucous membranes of the oral nasal empty, conjunctivitis. Oduzhannya nastє porivnyano shvidko. When there is anorexia, salivation, hyperemia of the mucous membranes of the oral nasal cavity. On the nasal dzercaltsі, lips, yasnas, vimenі, vulva to find virazki, bloodshed. The tongue is very swollen, it hangs out of the mouth, it’s a lot of hard work, and the thinness of the guinea wards. INODI sposterіgayutsya abortion, the birth of undead indifferent offspring. In the endemic episodes of overcoming the twigs of a great horned thinness, they often become asymptomatic, with trivial virosonism.
Pathologist zmіni. The corpses are visually impaired; Pіdshkіrna klіtkina і mіzhm'yazova is completely fabric in the head, the wide, the back knitted, the infiltrated zhivuvatoy ridge. Nabryaki can also be found in the middle of the open spaces, pharynx, larynx, tongue and lips. On the tongues, lips, inner surface of the face, the bloodshed are viral.
Selezіnka significantly zbіlshena in volume. Lymphatic nodes, especially deepthroat, halfhearted, shiiny and mesenterial, zbіlshenі, gіperemіyovanі, nabryakly. In breast and empty cows, the accumulation of a dragged exudate with blood houses can be spelled out. On the surface of the leg, the mucous membranes of the grassy canal and the dichal grooms, the capsule of the liver and the spleen, the epicardium and the endocardium are manifested in bloodshed.
The diagnosis shall be established on the basis of epizootological tributes, clinical signs of twigs, pathological anatomical signs and results of laboratory tests.
Laboratory diagnostics. Transfer of information from pathological materials to the virus, identification and identification of additional neutralization reactions (on smoking rooms and culture) for RIF, RZK, RDP, and other types of hospital ies In the case of large vipads, conduct a test on lambs.
For survival, send blood samples to the laboratory, take samples at the test temperature and take the sheep, and for post-mortem diagnosis, don’t have to pay attention to them twice a day.
In order to see the virus, it is necessary to carry out infection with the pathological material in the Zhovtkovsky kitty of 6 - 8-day-old smoking embryos, or in the judge of the KhAO 11 - 13-day-old smoking embryos. The specific death rate of infected embryos is present in 4-8 and 3-4 extras.
At times, for the view of the virus of cultural cultures, it is necessary to have 2 to 4 passages, first and lower because of the characteristic cytopathogenic nature of the monosphere. Identification of the virus is recognized for the additional neutralization reaction in the cultural culture, as well as for smoking embankments with an undetected specific syrovatka, as well as for the auxiliary RIF, RZK and RDP.
Identify serotype virus for plaque pH and the plaque method on an agar monosphere infected with Vero culture virus. A biological test should be carried out on 1–4-day-old targets, infect them intracerebrally, as well as on lambs of a 3–6-month-old infant, and some pathological material should be administered internally, internally, or abnormally.
Characteristic clinical signs of twigs appear after 6 - 8 days and appear in the elevated temperature, hyperemia of the mucous membranes of the mouth and nose, swollen lips and tongue. Experimentally infect lambs before being infected and after 21 - 30 days they will be infected by taking shelter and reaching for RZK. Appearance of specific complementations of juvenile antithesis about the manifestation of the material of the virus. Serodiagnosis and retrospective diagnostics of infectious catarrhal fumes of sheep should be carried out for the auxiliary RZK, RDP, RZGA, RN, and at times there are also RRH, RIF and ELISA methods. At the same time, convalescents of convalescence to reach RZK, for which you can see group-specific antibodies against all serotypes of spruce. Complementary antithesis is detected in blood after 2 hours of infection in credits of 1: 4 - 1: 16 and reach the maximum indicators (1: 60 - 1: 256) for the 30th add.
Differential diagnosis. Transmission of the need for exclusion of foot and mouth disease, contagious ectimies, sheep and cat, vesicular stomatitis, vispi, necrobacteriosis, Nairobi spruce, and rhizomes of the Rift valley. Foot and mouth disease, contagious ectima sheep and kiz, and vyspa sheep are characterized by a high contagiousness, their belts are not tied to sometimes with a massive amount of bloodsucking coma. For foot-and-mouth disease, the characteristics of aphthousnosis are obrazhennya mouth and mouth, vimenі, kintsovok; important results of higher education. In case of contagious knowledge, specific pustules are identified in the mucous membranes of the oral cavity and in the shaver in the length of the put, jack, and middle neck. At the hour of microscopic inspection of non-consumptive strokes and dry non-preserved scabs, see the spruce logs. Foot and mouth disease and vesicular stomatitis are differentiated on the basis of the results of RZK with antigen and antigen vesicles of the disease. To conduct a bioprobe on rabbits and lambs. I want you to pay attention to the results of microscopic purchases for Morozov smears on the inside of the top papules and on the background of the same preparation with the same dark brown and brown bouquets. In case of necrotic diseases, the prevailing behavior is to overcome, in the pathological material they appear the Fusobacterium necrophorum spruce. Twig Nairobi superconducted by the abdomen of hemorrhagic diathesis and severe gastroenteritis. For the Lyhomanka Rift Valley, the characteristic features are degeneration of the liver and middle necrosis. The residual diagnosis should be established for the results of laboratory tests.
Likuvannya not scattered.
Imunetet. Relocating creatures to imitate the name of the creature against that type of virus, having caused a twig. Mozhliva reinfektsiya іnshim type virusu for sale that very season chi offensive rock.
Active immunity in convalescence is superconducting to assimilation of neutral and complementary antithesis, and passively transmitted to young animals with colostrum. In dysfunctional countries for specific prophylaxis of infectious catarrhal fever, sheep have a lively and inactive vaccine. Imunitet and specific antibodies in high credits zbirigayutsya pislya vaccination not less than one pik.
Prevention and come on. The infectious catarrhal garyachka in our country is not registered. I’m grounded in the main respect for keeping in mind that I’ll be brought in with imported svіyskimi (vivtsi, goats, great horned thinness) and wild creepy creatures. Obov'yazkovim є prophylactic quarantine of all imported creatures at the time of consumption at the same time and serologic doslizhen. In dysfunctional countries, come in for prevention and treatment of ill health and health with veterinary legislation.
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