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Disorder of sexual function associated with metabolic disorders (nutritional impotence)

Etiology. Occurs in manufacturing bulls with protein overfeeding (the content in the diet is more than 50% of concentrated feed for the overall nutritional value), lack of carbohydrate in the diet (sugar-protein ratio less than 0.8: 1.0), vitamins (for 1 cu. less than 70 mg of carotene, 1500 IU of vitamin D and less than 40 mg of vitamin E), mineral substances (1 kg of calcium less than 7 g, phosphorus - 5 g, sodium chloride - 8 g, potassium - 19 g, magnesium - 5 g), as well as with a lack of trace elements (iodine, cobalt, zinc, copper, manganese, iron, etc.), feeding poor quality x feed and feed containing impurities of fluorine, arsenic, salts of heavy metals, keeping animals in poorly lit and insufficiently ventilated areas, in the absence of active daily walks.

Symptoms and course. Metabolic disorders manifest as endogenous toxicosis, acidosis, ketonemia, ketonuria, hyperproteinemia, hypoglycemia, diseases of the ligament tendon and bone apparatus (osteodystrophy), accompanied by disorder of biosynthesis, incretion and metabolism of sex hormones.

The initial stages of the disease are accompanied by the appearance of weakness and some pain in the hind limbs and a decrease in sexual activity. Clinical signs of impaired sexual apparatus may be absent. However, the germinal epithelium of the seminiferous tubules undergoes degenerative changes, which entails a violation and inhibition of spermatogenesis. The volume of ejaculate is reduced by 10-20%, the activity of sperm decreases to 6-7 points, their absolute survival rate to 1000 units. and less, dehydrogenase activity up to 20-25 tons, the number of pathological forms of sperm, especially those with defects of the tails, increases to 15-20% and dead to 15-25%. In the blood of such animals, the content of ketone bodies increases to 7-10 mg / 100 ml, estradiol - 17 beta to 45-60 pg / ml, the glucose content decreases to 36-38 mg / 100 ml, total calcium to 8-9.5 mg / 100ml, inorganic phosphorus up to 3.8-4 mg / 100ml, vitamin A up to 20-25 μg / 100ml, testosterone up to 1-3 ng / ml, alkaline reserve up to 40-45% vol. CO2. The content of ketone bodies in the urine is increased to 20 mg / 100 ml, total serum protein to 9.5-12 g / 100 ml. In some cases, there is a decrease in the amount of protein in the blood to 7.5 g / 100 ml.

With prolonged exposure to adverse factors and clinically expressed forms of metabolic disorders (osteodystrophy, ketosis, obesity), diffuse degeneration of the germinal epithelium of the seminiferous tubules develops in the sex glands of manufacturers.
Seed plants can maintain normal size, smooth surface, mobility, however, lose their elasticity and acquire a soft texture. There is a decrease in sexual activity, a weakening of the sexual reflexes and a significant deterioration in the quality indicators of sperm. The volume of ejaculate and sperm concentration is less than 6 points, the survival rate decreases to 400-600 units, dehydrogenase activity to 30 minutes or more, the number of pathological and dead sperm cells increases to 25-30% or more.

Subsequently, blood biochemical indices can level off, and the quality of sperm production remains low (oligospermatism, oligospermia, teratospermia, necrospermia).

Disruption of metabolism and reduction of sexual potency in manufacturing bulls may also be associated with adverse effects on their bodies of technologically unavoidable stress factors (operational, vaccinal, emotional and painful, climatic), accompanied by increased costs of plastic, energy resources and biologically active substances.

Treatment. To restore the impaired reproductive function of the manufacturing bulls, first of all, they correct the diets of animals, taking into account the norms of need, quality and chemical composition of feed, and organize active exercise. Animals additionally prescribed vitamins and microelements. For the first 7-10 days, for every 100 kg of body weight, vitamins and trace elements are fed: A - 70-80 thousand IU, D - 7-8 thousand IU, E - 70-80 mg and C - 250-300 mg, B1 - 0.05-0.06 mg, B2 - 0.4-0.5 mg, B12 - O, I-0.15 mg, copper sulphate - 100-150 mg, zinc sulphate - 250-300 mg, manganese sulphate - 300-400 mg, cobalt chloride - 6-10 mg, potassium iodide - 1.5-2.0 mg. Iodine is used in a stabilized form. In the subsequent periods of biologically active substances prescribed in half doses to normalize metabolism and reproductive ability of bulls. Against the background of a normalized metabolism, it is advisable to use twice the purified gonadotropin FFA at a dose of 4 mU / kg with an interval of 2-3 weeks.
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Disorder of sexual function associated with metabolic disorders (nutritional impotence)

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