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80. DIFFUSIVE DISEASES OF THE CONNECTIVE TISSUE. CLASSIFICATION. ETHIOLOGY, PATHOGENESIS. Systemic lupus erythematosus. CLINIC, DIAGNOSTICS, PRINCIPLES OF TREATMENT.

Diffuse diseases of the connective tissue (DBST) - a group of nosological forms, with systemic autoimmune and immuno-complex inflammation or excessive fibrozo formation (with systemic scleroderma) DBST includes: SLE, systemic scleroderma, dermatomyositis, Sjögren's syndrome, diffuse ectosis mixed connective tissue disease and polymyalgia rheumatism Etiology - it is possible to consider sexual factors (hyperestrogenemia) and the environment of the environment, such as infection, cooling, stress, unbalanced nutrition This is due to a family genetic predisposition to autoimmune reactions and hyperestrogenemia, which is the reason for the development of all these diseases mainly in women (20-30 years old). A feature of the pathogenesis of all DBST is the overproduction of autoantibodies to the components of the nucleus and cytoplasm of cells, Fc to receptors of immunoglobulins (rheumatoid factors), components of the coagulation system, phospholipids in combination with organ-specific autoimmune syndromes (Hashimoto's # thyroiditis). Autoimmune drugs are usually combined with an excess of circulating immune complexes, their deposition in target organs (skin, kidneys, lungs), blood vessels and the development of systemic immune-mediated inflammation. The development of autoimmune reactions, in turn, is associated with an increase in T-suppressor function and an increase in the activity of B-lymphocytes, which produce differentiation of autoantibodies. SLE is a chronic, progressive systemic disease, most often occurring in women. X-x is genetic determined by autoimmunity.
The clinic is the beginning for the most part with recurrent polyarthritis resembling rheumatic fever, an increase in 0t, different skin rashes, malaise and weakness, weight loss. Less commonly, an acute onset with high 0t, polyarthritis, severe skin syndrome, polyserositis, and nephritis. In 1/3 of patients, for many years, b-n has a monosyndromic character in the form of recurrent arthritis, polyserositis, Raynaud's syndrome, Vergolf, discoid lupus, epileptiform syndrome. The further course of x-x gradually involving various organs and systems in the process. The clinical picture is no polymorphic, with an uncontrollably progressive course, often fatal due to insufficient function of one or another organ or attachment of a secondary infection. Diagnostic criteria - erythema on the neck and nose, discoid rash, photodermatitis, ulcers in the mouth or nasopharynx, arthritis, serositis, kidney damage, central nervous system, hematologic narcia, immune narcia, antinuclear antibodies. If there is a 4 criterion, the diagnosis is reliable. Treatment - with the onset of subacute and xp, mainly articular versions of the course, NSAIDs are recommended. In case of XP, with predominantly skin lesions, quinoline preparations are recommended. Glucorticides are essential in the treatment of SLE. They are prescribed for exacerbation of pain, generalization of the process with the spread of the pathological process to the serous membranes, nervous system, heart, lungs, kidneys, etc.



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80. DIFFUSIVE DISEASES OF THE CONNECTIVE TISSUE. CLASSIFICATION. ETHIOLOGY, PATHOGENESIS. Systemic lupus erythematosus. CLINIC, DIAGNOSTICS, PRINCIPLES OF TREATMENT.

  1. 73. ACUTE DIFFUSIVE GLOMERULONEPHRITIS. ETHIOLOGY, PATHOGENESIS, CLINIC, DIAGNOSTIC, TREATMENT PRINCIPLES.
    Etiology -? -Hemolytic streptococcus gr. A. Patagenesis - 3-type allergic. reactions: the formation of immune complexes, their sedimentation on the membrane of the cells of the renal glomeruli> violation of the processes of filtration of protein, salts. Clinic - the first signs of b / w 1-3 weeks. after an infectious disease. Extrarenal Syndrome - weakness, headache, nausea, lower back pain, chills, v appetite, ^ 0t body
  2. LECTURE No. 9. Differential diagnosis of diffuse diseases of connective tissue in children. Clinic, diagnosis, treatment
    Classification of rheumatic diseases. 1. Rheumatism. 2. Juvenile rheumatoid arthritis. 3. Ankylosing spondylitis. 4. Other spondyloarthropathies. 5. Systemic lupus erythematosus. 6. Vasculitis: 1) hemorrhagic vasculitis (Shacklein-Genoa); 2) periarteritis nodosa (polyarteritis in young children, Kawasaki disease, Wegener's disease); 3) Takayasu arteritis. 7. Dermatomyositis. 8. Scleroderma. nine.
  3. 83. DIFFUSIVE TOXIC GOITER. ETIOLOGY, CLINIC, DIAGNOSTICS, TREATMENT PRINCIPLES.
    Diffuse toxic goiter - obstruction caused by increased thyroid activity. Etiology - psycho-trauma, infections (tonsillitis, rheumatism), changes in the function of other glands (pituitary gland), hereditary factors. The basis of pathogenesis is the narcissus of the immune “surveillance”, leading to the formation of autoantibodies, having their stimulating d, leading to hyperfunction, hyperplasia and hypertrophy of the gland. Changes in tissue sensitivity matter.
  4. 74. CHRONIC GLOMERULONEPHRITIS. ETHIOLOGY, PATHOGENESIS, CLINIC, DIAGNOSTIC, TREATMENT PRINCIPLES.
    kidney glomerular disease. Etiology is the outcome of OGN (? - hemolytic streptococcus), or occurs with systemic lupus erythematosus, hepatitis, and a snakebite. Pathogenesis is an autoimmune mechanism: autoAt to own kidney tissue. Clinic - Hematuric form - severe hematuria, swelling on the face, hypertension, signs of general intoxication, changes in the heart,
  5. 85. GAME. ETHIOLOGY, PATHOGENESIS, CLINIC, DIAGNOSTIC, TREATMENT PRINCIPLES.
    Gout - refers to the pain of metabolic “errors” and microcrystalline arthropathy, is associated with almost constant hyperuricemia (in the urine test) and the uric acid microcrystals in the tissues of the joint, kidney, vascular wall, less often the heart, eyes. Etiology - distinguish between primary (hereditary) gout - a defect in enzyme systems; secondary - leukemia during their treatment with cytostatics,
  6. 81. RHEUMATISM. ETHIOLOGY, PATHOGENESIS, CLINIC, DIAGNOSTICS, PRINCIPLES OF TREATMENT, PREVENTION.
    Rheumatism is a systemic inflammatory obstruction of the TC, with a predominantly local path process in various heart membranes, developing in persons predisposed to it, mainly at the age of 7-15 years. Etiology - infection with? -Hemolytic streptococcus of group A. Pathogenesis - a connection with 2 facts: 1) the toxic effects of a number of streptococcal enzymes with their cardiotoxic d. 2) the presence of
  7. 55. SYMPTOMATIC HYPERTENSIONS ETIOLOGY, PATHOGENESIS, CLINIC, DIAGNOSTIC, TREATMENT PRINCIPLES.
    processes as a symptom of other diseases are called secondary or symptomatic. Moreover, arterial hypertension often determines the severity of the underlying disease. Group Classification: 1. Hypertension caused by damage to the central nervous system. A small amount of the condition caused by traumatic brain injury, hypothalamic syndrome, Paige's diencephalic hypertensive syndrome, lesion
  8. 82. RHEUMATOID ARTHRITIS. ETHIOLOGY, PATHOGENESIS, CLINIC, DIAGNOSTIC, TREATMENT PRINCIPLES.
    Rheumatoid arthritis is a systemic inflammatory obstruction of the connective tissue with progressive erosive-destructive polyarthritis. Etiology - hereditary defects in the immune system. Pathogenesis - a glycosylation defect in Ig G therefore there will be no galactose and sialic acid, consequently conglomerates are formed from normal and abnormal Ig G, Ig M is produced on them
  9. 51. LUNG EMPHYSIS. ETHIOLOGY, PATHOGENESIS, CLINIC, DIAGNOSTIC, TREATMENT PRINCIPLES
    .Emphysema of the lungs - damage to the lungs, characterized by a decrease in the elastic properties of the lung tissue, a violation of the structure of the alveolar walls, expansion of the air spaces of the lungs distal to the terminal bronchioles with the fall of the latter on the exhale and obstruction of the airways. In most cases, panacinar pulmonary emphysema develops. Ethiology - factors contributing to the stretching of the air
  10. Chapter DIFFUSIVE DISEASES OF CONNECTIVE TISSUE
    Diffuse diseases of the connective tissue is a group of diseases that are characterized by a systemic type of inflammation of various organs and systems as a result of the combined development of autoimmune and immunocomplex processes, as well as excessive fibrosis. A feature of this group of diseases is the multifactorial type of predisposition with a specific role of immunogenetic
  11. Diffuse connective tissue diseases
    Diffuse diseases of the connective tissue (syn: collagenoses, collagen diseases) is a group concept that combines several diseases in which diffuse damage to the connective tissue and blood vessels is noted. In 1942, Klemperer (P. Klemperer) proposed calling diffuse collagen disease diseases that are anatomically characterized by generalized alteration (damage)
  12. Diffuse connective tissue diseases
    DIFFUSIVE DISEASES OF THE CONNECTIVE TISSUE (DZST), or collagenosis (a term having historical significance), is a group of diseases characterized by a systemic immuno-inflammatory lesion of the connective tissue and its derivatives. This concept is a group, but not nosological, in connection with which this term should not denote individual nosological forms. DZST combine enough
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