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DIFFUSIVE CONNECTIVE TISSUE DISEASES

By this concept is meant a number of nosological forms characterized by a systemic type of damage to various organs and systems, the development of autoimmune and immune complex processes, and excessive fibrosis.

In this lecture we will focus on three large collagenoses: systemic lupus erythematosus, systemic scleroderma and dermatomyositis. A few years ago, nodular periarteritis was also considered in this group, now this nosological form is referred to as systemic vasculitis, and we will not dwell on it.

The practical justification for combining all these diseases into one group, are: recurrent course, similarity in the early stages of development of individual clinical manifestations (Raynaud's syndrome, arthritis, fever, weight loss.
skin manifestations). general laboratory indicators of inflammatory activity, very similar anti-inflammatory and immunosuppressive therapy regimens, as well as a good effect after the application of extracorporeal treatment methods during periods of exacerbation.

But despite some similarities between the above symptoms, I would not want you to have a false idea of ​​connective tissue diseases as a faceless and homogeneous group of nosological forms. Each of the diseases under consideration has clinical etiopathogenetic and laboratory features unique to it, which give rise to thought in the differential diagnosis and allow in most cases to make the correct diagnosis.
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DIFFUSIVE CONNECTIVE TISSUE DISEASES

  1. Chapter DIFFUSIVE DISEASES OF CONNECTIVE TISSUE
    Diffuse diseases of the connective tissue is a group of diseases that are characterized by a systemic type of inflammation of various organs and systems as a result of the combined development of autoimmune and immunocomplex processes, as well as excessive fibrosis. A feature of this group of diseases is the multifactorial type of predisposition with a specific role of immunogenetic
  2. Diffuse connective tissue diseases
    Diffuse diseases of the connective tissue (syn: collagenoses, collagen diseases) is a group concept that combines several diseases in which diffuse damage to the connective tissue and blood vessels is noted. In 1942, Klemperer (P. Klemperer) proposed calling diffuse collagen disease diseases that are anatomically characterized by generalized alteration (damage)
  3. Diffuse connective tissue diseases
    DIFFUSIVE DISEASES OF THE CONNECTIVE TISSUE (DZST), or collagenosis (a term having historical significance), is a group of diseases characterized by a systemic immuno-inflammatory lesion of the connective tissue and its derivatives. This concept is a group, but not nosological, in connection with which this term should not denote individual nosological forms. DZST combine enough
  4. Diffuse connective tissue diseases
    Diffuse connective diseases
  5. DIFFUSIVE DISEASES OF THE CONNECTIVE TISSUE AND JOINTS
    DIFFUSIVE DISEASES OF THE CONNECTIVE TISSUE AND
  6. NERVOUS SYSTEM DISEASE IN RHEUMATISM AND OTHER DIFFUSIVE DISEASES OF CONNECTIVE TISSUE
    Recently, rheumatic lesions of the nervous system are considered as a primary, systemic, gradually developing destructive process in the connective tissue. The term “collagenoses” was proposed by Klemperer and Ber in 1940. Based on the morphological characteristics of systemic lesions of the connective tissue, they combined a number of diseases into a group of collagenoses. It was later established that in
  7. 80. DIFFUSIVE DISEASES OF THE CONNECTIVE TISSUE. CLASSIFICATION. ETHIOLOGY, PATHOGENESIS. Systemic lupus erythematosus. CLINIC, DIAGNOSTICS, PRINCIPLES OF TREATMENT.
    Diffuse diseases of the connective tissue (DBST) - a group of nosological forms, x-systemic autoimmune and immuno-complex inflammation or excessive fibrozo formation (with systemic scleroderma) DBST includes: SLE, systemic scleroderma, dermatomyositis, Sjogren's syndrome, diffuse ectosis mixed connective tissue disease and rheumatic polymyalgia Etiology - possible
  8. Topic number 6. Diffuse diseases of the connective tissue. Bubble Dermatoses
    Lupus erythematosus is a serious disease that affects connective tissue and blood vessels. Among the factors that provoke the appearance or exacerbation of lupus erythematosus, first of all, there is an increased sensitivity to insolation and meteorological influences. In some cases, in women, the disease occurs after pregnancy and childbirth. Distinguish between chronic (limited and disseminated) and systemic
  9. LECTURE No. 9. Differential diagnosis of diffuse diseases of connective tissue in children. Clinic, diagnosis, treatment
    Classification of rheumatic diseases. 1. Rheumatism. 2. Juvenile rheumatoid arthritis. 3. Ankylosing spondylitis. 4. Other spondyloarthropathies. 5. Systemic lupus erythematosus. 6. Vasculitis: 1) hemorrhagic vasculitis (Shacklein-Genoa); 2) periarteritis nodosa (polyarteritis in young children, Kawasaki disease, Wegener's disease); 3) Takayasu arteritis. 7. Dermatomyositis. 8. Scleroderma. 9.
  10. Cross syndrome and mixed connective tissue disease
    A. The clinical picture. A mixed connective tissue disease is characterized by a combination of symptoms of scleroderma, rheumatoid arthritis, polymyositis and SLE. About 10% of SLE patients meet the criteria for mixed connective tissue disease developed by the American Rheumatological Association. Usually a mixed connective tissue disease is most reminiscent of scleroderma.
  11. Types of connective tissue.
    {foto11} Connective tissue. From left to right: loose connective tissue, dense connective tissue, cartilage, bone, blood. Loose connective tissue consists of cells scattered in the intercellular substance, and intertwined disordered fibers. Wavy bundles of fibers consist of collagen, and straight ones of elastin; their combination provides the strength and elasticity of the connective
  12. Abstract. Biochemistry of bone and connective tissue., 2008
    single fabric. Composition and structure. Glucosaminoglycans. Glycoproteins. Fibers of connective tissue. Collagen synthesis. Biochemical changes in connective tissue during aging and some pathological processes. Factors that regulate the metabolism of connective tissue. Bone. Osteoblast. Osteocyte. Osteoclast. The chemical composition of bone tissue. Bone formation. Factors
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