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Subject: Physiology and biochemistry of viruses

Physiology and biochemistry of viruses. The chemical composition of viral particles: nucleic acids, proteins, lipids, carbohydrates and their features. The concept of simple and complex viruses. Enzymes of viruses and their classification.

The mechanism of hemagglutination and hemadsorption of viruses.

Propagation of viruses. The main stages of the interaction of viruses and cells. Stage adsorption, characteristics of viral and cellular receptors. The stage of penetration into the cell, its mechanism. Stages of deproteinization, synthesis of viral macromolecules, assembly of viral particles and exit from the cell, their mechanisms in various groups of viruses.

Interference. Defective interfering particles and their importance in the development of viral infection. Satellite viruses.

Types of interaction between viruses and cells: productive, abortive, integrative.


Methods for the cultivation of viruses: in cell cultures, chicken embryos, in animals and their assessment. Classification of cell cultures used in virology. Characterization of the cytopathogenic effect of viruses in cell cultures. Classification of types of cytopathogenic action. Viral inclusions. Plaque formation on agar and bentonite coatings, practical significance.

Methods for titration of viruses (RGA, etc.).

Virus identification using immunity reactions - PH, RSK, RTGA, RP, ELISA, RIA, RIF, etc. Laboratory diagnostic methods for viral infections: microscopic, virological, serological.
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Subject: Physiology and biochemistry of viruses

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  2. FEATURES OF CLINICAL PHYSIOLOGY AND BIOCHEMISTRY OF THE CENTRAL NERVOUS SYSTEM
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  3. Topic: Genetics of viruses
    The importance of virology in the development of genetics. Organization of the genetic apparatus of viruses. Differences in the genomes of RNA and DNA viruses. Modification variability of viruses: phenotypic mixing, polyploidy. Types of genetic variation in viruses: mutacin, recombination, errors in copying genomes. Mutations in viruses and their classification. Spontaneous and induced mutations,
  4. Subject: Systematics and nomenclature of viruses
    The kingdom of viruses. Definition of viruses as special forms of living organization. Human, animal, insect, plant, bacteria viruses. Viroids, prions. Principles of classification and taxonomy of viruses: family, genus,
  5. Topic: Virus Structure
    The principles of structural organization of viruses. Virion and its components. Nucleic acid, capsid, capsomeres, supercapsid membrane, peplomeres. Types of symmetry
  6. Topic: History of the doctrine of viruses
    The main stages of the development of virology. Discovery D.I. Ivanovsky viruses, the significance of this discovery for biology and medicine. Determination of the significance of viruses in the pathology of humans and animals. Substantiation of virus cultivation methods (in laboratory animals, chicken embryos, cell cultures). The study of morphology using an electron microscope. Basic research
  7. Subject: VIRUSES - THE INFECTIOUS HUMAN DISEASES
    4.1. DNA genomic viruses. 4.1.1. Poxviruses (Poxviridae family). General characteristics and classification. Smallpox virus. The structure of the virion. Antigens. Cultivation. Sensitivity to chemical and physical factors. Hemagglutination. Pathogenetic features of the disease. Laboratory diagnostics. Intracellular inclusions (Guarnieri bodies). Specific
  8. Subject: VIRUSES - THE INFECTIOUS HUMAN DISEASES
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  13. Abstract. Viruses. Features of ontogenesis and the reproduction cycle of DNA and RNA-containing viruses., 2008
    Features of ontogenesis and the reproduction cycle of DNA and RNA-containing viruses. Viruses, the features of their structure and activity. Classification. differences, structures,
  14. The cultivation of human influenza viruses in the laboratory, the circle of hosts among laboratory animals and the isolation of the virus from clinical material
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  15. Biochemistry of a traumatic disease
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